alpha-Galactosidase A/GLA Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-89796

Novus Biologicals, part of Bio-Techne
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NBP1-89796
NBP1-89796-25ul
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Validated:

Human, Mouse

Cited:

Mouse

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all alpha-Galactosidase A/GLA Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: HISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGT

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 25915924).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for alpha-Galactosidase A/GLA Antibody

Immunohistochemistry-Paraffin: alpha-Galactosidase A/GLA Antibody [NBP1-89796]

Immunohistochemistry-Paraffin: alpha-Galactosidase A/GLA Antibody [NBP1-89796]

Immunohistochemistry-Paraffin: alpha-Galactosidase A/GLA Antibody [NBP1-89796] - Analysis in human seminal vesicle and skeletal muscle tissues. Corresponding GLA RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: alpha-Galactosidase A/GLA Antibody [NBP1-89796]

Immunohistochemistry-Paraffin: alpha-Galactosidase A/GLA Antibody [NBP1-89796]

Immunohistochemistry-Paraffin: alpha-Galactosidase A/GLA Antibody [NBP1-89796] - Staining of human adrenal gland, colon, liver and testis using Anti-GLA antibody NBP1-89796 (A) shows similar protein distribution across tissues to independent antibody NBP1-89797 (B).
Immunohistochemistry-Paraffin: alpha-Galactosidase A/GLA Antibody [NBP1-89796]

Immunohistochemistry-Paraffin: alpha-Galactosidase A/GLA Antibody [NBP1-89796]

Immunohistochemistry-Paraffin: alpha-Galactosidase A/GLA Antibody [NBP1-89796] - Staining of human duodenum shows moderate positivity in lysosomes in glandular cells.
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Applications for alpha-Galactosidase A/GLA Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: alpha-Galactosidase A/GLA

Galactosidase alpha encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq]

Alternate Names

Agalsidase alpha, GALA, Melibiase

Gene Symbol

GLA

Additional alpha-Galactosidase A/GLA Products

Product Documents for alpha-Galactosidase A/GLA Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for alpha-Galactosidase A/GLA Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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