AMPK alpha 1/2 [p Thr172] Antibody (SR2077)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21537

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21537-100ul
NBP3-21537-50ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2077

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all AMPK alpha 1/2 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human phospho-AMPK alpha 1/2 [Thr172] (Uniprot #: Q13131, P54646)

Modification

p Thr 172

Specificity

Detects endogenous levels of phospho-AMPK alpha 1/2 [Thr172]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

62 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for AMPK alpha 1/2 [p Thr172] Antibody (SR2077)

Western Blot: AMPK alpha 1/2 [p Thr 172] Antibody (SR2077) [NBP3-21537] -

Western Blot: AMPK alpha 1/2 [p Thr 172] Antibody (SR2077) [NBP3-21537] - Western blot analysis using NBP3-21537 in Mouse heart lysate.

Applications for AMPK alpha 1/2 [p Thr172] Antibody (SR2077)

Application
Recommended Usage

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: AMPK alpha 1/2

AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic a subunit and regulatory beta and gamma subunits. Each subunit exists as alternate isoforms (alpha 1, alpha 2, beta 1, beta 2, gamma 1, gamma 2, gamma 3), with all 12 combinations capable of forming complexes. The catalytic a subunit of AMPK is activated allosterically by AMP and by phosphorylation via the AMPK kinase LKB1. Active AMPK downregulates anabolic pathways such as fatty acid, triglyceride, and cholesterol synthesis, and up-regulates catabolic pathways such as glycolysis and fatty acid oxidation. AMPK's role in metabolic regulation has implicated this serine/threonine kinase as a therapeutic target in heart disease, obesity, and diabetes.

Long Name

AMP-activated Protein Kinase alpha 1/2

Alternate Names

AMPK, AMPKa1, PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit

Gene Symbol

PRKAA1

Additional AMPK alpha 1/2 Products

Product Documents for AMPK alpha 1/2 [p Thr172] Antibody (SR2077)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for AMPK alpha 1/2 [p Thr172] Antibody (SR2077)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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