Androgen R/NR3C4 Antibody (rDHTR/8818)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-23812

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-23812-20ug
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Mouse IgG Kappa Clone # rDHTR/8818

Concentration

0.2 mg/ml

View all Androgen R/NR3C4 Antibodies »

Product Specifications

Immunogen

Recombinant full-length human Androgen R/NR3C4 protein

Localization

Nucleus.

Marker

Marker of Androgen Dependence

Clonality

Monoclonal

Host

Mouse

Isotype

IgG Kappa

Description

Store at 2 to 8C. Non-hazardous. No MSDS required.

Scientific Data Images for Androgen R/NR3C4 Antibody (rDHTR/8818)

Androgen R/NR3C4 Antibody (rDHTR/8818)

Immunohistochemistry-Paraffin: Androgen R/NR3C4 Antibody (rDHTR/8818) [NBP3-23812] -

Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Androgen R/NR3C4 antibody (rDHTR/8818). HIER: Tris/EDTA, pH9.0, 45min. Secondary: HRP-polymer, 30min. DAB, 5min.

Applications for Androgen R/NR3C4 Antibody (rDHTR/8818)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1-2ug/ml
Application Notes
Immunohistochemistry-Paraffin: 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

1mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Androgen R/NR3C4

Androgens have a broad range of effects on the appearance and maintenance of male secondary sexual characteristics. Like other members of the steroid superfamily, the androgen receptor (AR) consists of an amino terminal modulating domain, a central DNA binding domain, a hinge region and a carboxy terminal ligand binding domain. The androgen receptor (AR) is a 110 kDa androgen-dependent transcription factor that is a member of the steroid/nuclear receptor gene superfamily. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease and male infertility. The PI3K/Akt signaling pathway plays an important role in regulating AR activity through phosphorylation of AR at Ser213/210 and Ser791/790. Growth factors or cytokines may induce phosphorylation of AR through the PI3K/Akt pathway. Activation of the PI3K/AKt pathway is thought to have a survival role in prostate cancer by protecting cells from apoptosis.

Long Name

Androgen Receptor

Alternate Names

AIS, AndrogenR, AR, DHTR, NR3C4, SBMA, SMAX1

Gene Symbol

AR

Additional Androgen R/NR3C4 Products

Product Documents for Androgen R/NR3C4 Antibody (rDHTR/8818)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Androgen R/NR3C4 Antibody (rDHTR/8818)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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