Angiostatin Antibody (GMA-013)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-29812

Novus Biologicals, part of Bio-Techne
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NBP2-29812
NBP2-29812-0.025mg
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgM Clone # GMA-013

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Angiostatin Antibodies »

Product Specifications

Immunogen

Purified human plasminogen.

Reactivity Notes

Human

Specificity

Plasminogen (kringles 1-3).

Clonality

Monoclonal

Host

Mouse

Isotype

IgM

Theoretical MW

88 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

Relevant Entrez Gene Numbers: NM_000301

Scientific Data Images for Angiostatin Antibody (GMA-013)

Western Blot: Angiostatin Antibody (GMA-013) [NBP2-29812]

Western Blot: Angiostatin Antibody (GMA-013) [NBP2-29812]

Western Blot: Angiostatin Antibody (GMA-013) [NBP2-29812] - 2ug of human plasminogen/angiostatin was probed with anti-Plasminogen/Angiostatin, clone GMA-013 (1ug/ml). Arrow indicates plasminogen (~88kDa).

Applications for Angiostatin Antibody (GMA-013)

Application
Recommended Usage

ELISA

1:100-1:2000

Western Blot

1:100-1:2000

Formulation, Preparation, and Storage

Purification

Ion exchange chromatography

Formulation

Phosphate buffered saline with 1% (w/v) mannitol, pH 7.4.

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Angiostatin

Plasminogen is the precursor of plasmin, an active serine protease that dissolves the fibrin of blood clots and acts in many other processes such as embryonic development, tissue remodeling, inflammation and tumor invasion. Synthesized in the kidney, plasminogen is found in plasma and many extracellular fluids. Activated by u- or t-plasminogen activator, the single-chain plasminogen is converted to plasmin that consists of a disulfide bond-linked heavy chain A and light chain B. Heavy chain A contains 5 kringle domains and light chain B corresponds to the serine protease domain. A fragment consisting of the first 4 kringle domains has been named angiostatin, a novel angiogenesis inhibitor.

Alternate Names

HAE4

Gene Symbol

PLG

UniProt

P00747

Additional Angiostatin Products

Product Documents for Angiostatin Antibody (GMA-013)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Angiostatin Antibody (GMA-013)

Relevant Entrez Gene Numbers: NM_000301

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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