APBB2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-84700

Novus Biologicals, part of Bio-Techne
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NBP1-84700
NBP1-84700-25ul
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Key Product Details

Validated by

Knockout/Knockdown

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Knockdown Validated, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all APBB2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: SEKLEGKEPHPQDSSSCEILPSQPRRTKSFLNYYADLETSARELEQNRGNHHGTAEEKSQPVQGQASTIIGNGDLLLQKPNRPQSSPEDGQVATVSSSPETKKDHPKTGAKTDCALHRIQNLAPS

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (85%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for APBB2 Antibody

Western Blot: APBB2 Antibody [NBP1-84700]

Western Blot: APBB2 Antibody [NBP1-84700]

Western Blot: APBB2 Antibody [NBP1-84700] - Analysis in control (vector only transfected HEK293T lysate) and LY406673 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).
Immunocytochemistry/ Immunofluorescence: APBB2 Antibody [NBP1-84700]

Immunocytochemistry/ Immunofluorescence: APBB2 Antibody [NBP1-84700]

Immunocytochemistry/Immunofluorescence: APBB2 Antibody [NBP1-84700] - Staining of human cell line U-251MG shows positivity in mitochondria.
Immunohistochemistry-Paraffin: APBB2 Antibody [NBP1-84700]

Immunohistochemistry-Paraffin: APBB2 Antibody [NBP1-84700]

Immunohistochemistry-Paraffin: APBB2 Antibody [NBP1-84700] - Staining of human pancreas shows distinct granular positivity in exocrine cells.
View 1 more images

Applications for APBB2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: APBB2

Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the beta-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down's syndrome and a variety of neurological disorders, including Alzheimer's disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the 4 kDa Amyloid ®/A4 protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane- bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer disease patients.

Alternate Names

amyloid beta (A4) precursor protein-binding, family B, member 2, amyloid beta A4 precursor protein-binding family B member 2, DKFZp434E033, FE65L1FE65LMGC35575, Fe65-like 1, Protein Fe65-like 1

Entrez Gene IDs

323 (Human)

Gene Symbol

APBB2

UniProt

Q92870 (Human)

Additional APBB2 Products

Product Documents for APBB2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for APBB2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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