Apelin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-31176

Novus Biologicals, part of Bio-Techne
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NBP2-31176
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Porcine, Sheep

Cited:

Mouse, Porcine, Ovine

Applications

Validated:

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

IF/IHC, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

LYOPH mg/ml

View all Apelin Antibodies »

Product Specifications

Immunogen

Synthetic peptide derived from C terminal region of human Apelin

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 31767185). Sheep reactivity reported in scientific literature (PMID: 31412301). Use in Porcine reported in secitific publication PMID: 32456363

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Apelin Antibody

Immunohistochemistry-Paraffin: Apelin Antibody [NBP2-31176]

Immunohistochemistry-Paraffin: Apelin Antibody [NBP2-31176]

Immunohistochemistry-Paraffin: Apelin Antibody [NBP2-31176] - Staining of human isolated adipocytes. Antibody dilution 1:2000.

Applications for Apelin Antibody

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

1:10-1:500
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Lyophilized powder. Reconstitute in 100ul distilled water.

Formulation

Tris 0,1M, glycine 0,1M, sucrose 2%

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Apelin

Apelin is a neuropeptide expressed in the supraoptic and paraventricular nuclei and is an endogenous ligand for APJ, a G protein-coupled orphan receptor which is an alternative coreceptor with CD4 for HIV-1. Apelin and APJ are ubiquitously expressed in peripheral tissues, with highest levels reported for heart and lungs, as well several regions within the central nervous system. The actions of apelin remain largely unknown: Apelin inhibits HIV-1 entry in cells coexpressing CD4 and APJ; the oral intake of Apelin in colostrum and breast milk could have a role in the modulation of the immune responses in neonates; more recent studies have also indicated a role for Apelin in the central control of body fluid homeostasis, by influencing AVP release and drinking behavior. In the cardiovascular system several actions of Apelin have been described, including endothelium-dependent vasodilatation, vasoconstriction through direct action on smooth muscle and positive inotropism.

Alternate Names

AGTRL1 Lligand, APEL, APLN, XNPEP2

Gene Symbol

APLN

Additional Apelin Products

Product Documents for Apelin Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Apelin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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