APIP Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56383

Novus Biologicals, part of Bio-Techne
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NB100-56383
NB100-56383SS
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all APIP Antibodies »

Product Specifications

Immunogen

The antibody was developed against a full-length His-tagged recombinant APIP protein (NP_057041).

Specificity

This polyclonal can be used for detection of APIP and APIP2.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for APIP Antibody

Western Blot: APIP Antibody [NB100-56383]

Western Blot: APIP Antibody [NB100-56383]

Western Blot: APIP Antibody [NB100-56383] - Analysis of APIP 2 in human muscle using this antibody at 2 ug/ml.
Immunohistochemistry-Paraffin: APIP Antibody [NB100-56383]

Immunohistochemistry-Paraffin: APIP Antibody [NB100-56383]

Immunohistochemistry-Paraffin: APIP Antibody [NB100-56383] - Formalin-fixed, paraffin-embedded human kidney tissue probed with this antibody at 5 ug/ml.

Applications for APIP Antibody

Application
Recommended Usage

Immunohistochemistry

5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.2% gelatin

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: APIP

The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1) (1,2). Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Recently, Cho et al (4) have identified a new Apaf-1 Interacting Protein (APIP) also known as CG129 and MMRP19, as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N-terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.

Alternate Names

APAF1 interacting protein, APAF1-interacting protein, APIP2, CGI29, CGI-29, dJ179L10.2, EC 4.2.1.109, MMRP19, MTRu-1-P dehydratase, probable methylthioribulose-1-phosphate dehydratase

Entrez Gene IDs

51074 (Human)

Gene Symbol

APIP

UniProt

Q96GX9 (Human)

Additional APIP Products

Product Documents for APIP Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for APIP Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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