Apolipoprotein E/ApoE Antibody (3D12)

Immunohistochemistry: Apolipoprotein E/ApoE Antibody (3D12) [NBP1-97424]

Immunohistochemistry: Apolipoprotein E/ApoE Antibody (3D12) [NBP1-97424] - Abeta12-28P treatment reduces soluble and insoluble brain apoE levels and apoE deposition in Abeta plaques in APP/E2 and APP/E4 mice. Representative microphotographs of coronal sections through the sensorimotorcortex at the level of the posterior caudate-putamen from vehicle- and Abeta12-28P-treated APP/E2 and APP/E4 mice, whichwere immunostained against human apoE. White arrowheads indicate apoE positive deposits. Scalebar 200 um. Abbreviations: cc, corpus callosum; CPu, caudate-putamen; NCtx, neocortex. Image collected and cropped by CiteAb from the following publication (actaneurocomms.biomedcentral.com/articles/10.1186/s40478-014-0075-0), licensed under a CC-BY license.

Immunocytochemistry/ Immunofluorescence: Apolipoprotein E/ApoE Antibody (3D12) [NBP1-97424] -

Immunocytochemistry/ Immunofluorescence: Apolipoprotein E/ApoE Antibody (3D12) [NBP1-97424] - A beta12-28P treatment reduces soluble andinsoluble brain apoE levels & apoE deposition in A betaplaques in APP/E2 & APP/E4 mice. Levels ofsoluble (diethylamine-extractable) human apoE (A) & those of insoluble(formic-acid-extractable) human apoE (B). Values are mean (±SEM) in 11–12 animalsof APP/E2 background & 8 animals of APP/E4 background.(C) Representativemicrophotographs of coronal sections through the sensorimotorcortex at the level of the posterior caudate-putamen fromvehicle- & A beta12-28P-treated APP/E2 & APP/E4 mice, whichwere immunostained against human apoE. White arrowheadsindicate apoE positive deposits. (D) Mean (±SEM) human apoE positive plaqueload in the neocortex & the hippocampus (n = 7–8/group).(A, B, D) * p < 0.05, ** p < 0.01, *** p < 0.001, *** p < 0.0001, versusvehicle-treated mice of the same APOE background (Student’st test).##p < 0.01,####p < 0.0001,vehicle-treated APP/E2 mice vs. vehicle-treated APP/E4 mice(Student’s t test). Scalebar 200 μm (C).Abbreviations: cc, corpus callosum; CPu, caudate-putamen;NCtx, neocortex. Image collected & cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/24972680), licensed under a CC-BY license. Not internally tested by Novus Biologicals.