Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all ARC Antibodies »

Product Specifications

Immunogen

Antibody was raised against an 18 amino acid peptide near the carboxy terminus of human ARC. The immunogen is located within the last 50 amino acids of ARC. Amino Acid Squence: PDPEPEPDFEERDESEDS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

25 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for ARC/NOL3 Antibody - BSA Free

Western Blot: ARC/NOL3 AntibodyBSA Free [NBP2-41753]

Western Blot: ARC/NOL3 AntibodyBSA Free [NBP2-41753]

Western Blot: ARC/NOL3 Antibody [NBP2-41753] - ARC in HeLa (H), KB (K), and A549 (A) whole cell lysates with anti-ARC (CT) at a 1:1000 dilution.
Immunohistochemistry-Paraffin: ARC/NOL3 Antibody - BSA Free [NBP2-41753]

Immunohistochemistry-Paraffin: ARC/NOL3 Antibody - BSA Free [NBP2-41753]

Immunohistochemistry-Paraffin: ARC/NOL3 Antibody [NBP2-41753] - Human skeletal muscle with ARC/NOL3 antibody at 5 ug/mL.

Applications for ARC/NOL3 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ARC

Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue.

Long Name

Apoptosis Repressor with Caspase Recruitment Domain

Alternate Names

NOL3

Gene Symbol

NOL3

UniProt

NP_003937 (Human)

Additional ARC Products

Product Documents for ARC/NOL3 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for ARC/NOL3 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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