Argininosuccinate Lyase Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-55124

Novus Biologicals, part of Bio-Techne
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NBP1-55124
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all Argininosuccinate Lyase Antibodies »

Product Summary for Argininosuccinate Lyase Antibody

Immunogen

Synthetic peptides corresponding to ASL(argininosuccinate lyase) The peptide sequence was selected form the N terminal of ASL. Peptide sequence GATAGKLHTGRSRNDQVVTDLRLWMRQTCSTLSGLLWELIRTMVDRAEAE. The peptide sequence for this immunogen was taken from within the described region.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Scientific Data Images for Argininosuccinate Lyase Antibody

Western Blot: Argininosuccinate Lyase Antibody [NBP1-55124]

Western Blot: Argininosuccinate Lyase Antibody [NBP1-55124]

Western Blot: Argininosuccinate Lyase Antibody [NBP1-55124] - Transfected 293T cell lysate, concentration 0.2-1 ug/ml.

Applications for Argininosuccinate Lyase Antibody

Application
Recommended Usage

Western Blot

1.0 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Argininosuccinate Lyase

ASL is a member of the lyase 1 family. The protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in its gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency.This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.

Alternate Names

argininosuccinase, argininosuccinate lyase, Arginosuccinase, ASAL, EC 4.3.2.1

Gene Symbol

ASL

OMIM

NP_000039 (Human)

UniProt

P04424 (Human)

Additional Argininosuccinate Lyase Products

Product Documents for Argininosuccinate Lyase Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Argininosuccinate Lyase Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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