Ataxin 1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-90065

Novus Biologicals, part of Bio-Techne
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NBP1-90065
NBP1-90065-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Ataxin 1 Antibodies »

Product Summary for Ataxin 1 Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: RAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHP

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (81%), Rat (81%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Ataxin 1 Antibody

Immunohistochemistry-Paraffin: Ataxin 1 Antibody [NBP1-90065]

Immunohistochemistry-Paraffin: Ataxin 1 Antibody [NBP1-90065]

Immunohistochemistry-Paraffin: Ataxin 1 Antibody [NBP1-90065] - Staining of human prostate shows weak to moderate nuclear positivity in smooth muscle cells.
Immunohistochemistry-Paraffin: Ataxin 1 Antibody [NBP1-90065]

Immunohistochemistry-Paraffin: Ataxin 1 Antibody [NBP1-90065]

Immunohistochemistry-Paraffin: Ataxin 1 Antibody [NBP1-90065] - Staining of human cerebral cortex shows strong nuclear positivity in neuronal cells.
Immunohistochemistry-Paraffin: Ataxin 1 Antibody [NBP1-90065]

Immunohistochemistry-Paraffin: Ataxin 1 Antibody [NBP1-90065]

Immunohistochemistry-Paraffin: Ataxin 1 Antibody [NBP1-90065] - Staining of human lymph node shows moderate nuclear positivity in germinal center cells.

Applications for Ataxin 1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Ataxin 1

Defects in Ataxin-1 are the cause of spinocerebellar ataxia type 1 (SCA1), also known as olivopontocerebellar atrophy I (OPCA I or OPCA1). Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA1 is caused by expansion of a CAG repeat in the coding region of the ataxin-1 gene. Longer expansions result in earlier onset and more severe clinical manifestations of the disease. Ataxin-1 binds RNA in vitro and may be involved in RNA metabolism. [Uniprot]

Alternate Names

ataxin 1, ataxin 1), ataxin-1, ATX1spinocerebellar ataxia 1 (olivopontocerebellar ataxia 1, autosomal dominant, SCA1D6S504E, Spinocerebellar ataxia type 1 protein

Gene Symbol

ATXN1

Additional Ataxin 1 Products

Product Documents for Ataxin 1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Ataxin 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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