Ataxin 7 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-10469

Novus Biologicals, part of Bio-Techne
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NBP3-10469-100ul
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Key Product Details

Species Reactivity

Validated:

Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

0.5 mg/ml

View all Ataxin 7 Antibodies »

Product Summary for Ataxin 7 Antibody

Immunogen

The immunogen is a synthetic peptide directed towards the N-terminal region of Rat Ataxin 7 (XP_001069337). Peptide sequence MSERAADDVRGEPRRAAGGAAAARQQQQPQPLQLQRQHPPPRRPRPEDGG

Clonality

Polyclonal

Host

Rabbit

Theoretical MW

92 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Ataxin 7 Antibody

Western Blot: Ataxin 7 Antibody [NBP3-10469]

Western Blot: Ataxin 7 Antibody [NBP3-10469]

Western Blot: Ataxin 7 Antibody [NBP3-10469] - Western blot analysis of Ataxin 7 in Rat Small Intestine lysates. Antibody dilution at 1.0ug/ml

Applications for Ataxin 7 Antibody

Application
Recommended Usage

Western Blot

1.0 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Ataxin 7

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with Spinocerebellar ataxia-7, contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The exact function of this gene is not known, however, since the encoded protein contains a nuclear localization sequence, and is found to be localized in the nucleus, it has been postulated to be a potential transcription factor. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. (provided by RefSeq)

Alternate Names

ADCAII, ataxin 7, FLJ17787, SCA7

Gene Symbol

ATXN7

Additional Ataxin 7 Products

Product Documents for Ataxin 7 Antibody

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Certificate of Analysis

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Product Specific Notices for Ataxin 7 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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