ATG11 Antibody (7C2NB)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-47124

Novus Biologicals, part of Bio-Techne
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NBP2-47124
NBP2-47124SS
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Key Product Details

Species Reactivity

Yeast

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgM Lambda Clone # 7C2NB

Concentration

1.0 mg/ml

View all ATG11 Antibodies »

Product Specifications

Immunogen

Partial recombinant protein made to an internal sequence of the S. cerevisiae ATG11 protein (between amino acids 50-250) [UniProt Q12527]

Clonality

Monoclonal

Host

Mouse

Isotype

IgM Lambda

Scientific Data Images for ATG11 Antibody (7C2NB)

Western Blot: ATG11 Antibody (7C2NB) [NBP2-47124]

Western Blot: ATG11 Antibody (7C2NB) [NBP2-47124]

Western Blot: ATG11 Antibody (7C2NB) [NBP2-47124] - Western blot analysis of ATG11 antibody in partial recombinant ATG11 protein.

Applications for ATG11 Antibody (7C2NB)

Application
Recommended Usage

Western Blot

0.5 ug/ml

Formulation, Preparation, and Storage

Purification

IgM purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ATG11

ATG11 (autophagy-related protein 11), also called cytoplasm to vacuole targeting protein 9/CVT9, is expressed in Saccharomyces cerevisiae (Baker's Yeast). As a scaffold protein and a selective autophagy adaptor, it interacts with several different cargo receptors to mediate various kind of selective autophagy. Atg11 recognizes and transports substrates to the pre-autophagosomal structure/PAS, the site of autophagosome formation. ATG11 was identified by Lipatova et al and they found it to be an effector of the Rab Ypt1 and the TRAPPIII complex during selective macroautophagy. ATG11 is now known to bind with Atg19, Atg32, Atg36 etc. and it involves in cytoplasm to vacuole transport/CVT pathway, pexophagy, mitophagy and nucleophagy. Atg11 interacts with Atg1 and Atg17 also, which connects the cargo selection step to autophagosome formation. ATG11 gets recruited to the degrading mitochondria by ATG32, and Atg11 in turn brings Dnm1 as well as other proteins implicated in mitochondrial fission to the affected mitochondria for promoting their division. ATG11 is essential for ATG9 anterograde transport from the mitochondria to the PAS and it recruits ATG19-prAPE1 complex also to the PAS.

Alternate Names

CVT3, CVT9

Gene Symbol

ATG11

Additional ATG11 Products

Product Documents for ATG11 Antibody (7C2NB)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for ATG11 Antibody (7C2NB)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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