Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all ATOH8 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ATOH8. The immunogen is located within the last 50 amino acids of ATOH8. Amino Acid Squence: TRTLQAEGRAKKRKE

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

40 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for ATOH8 Antibody - BSA Free

Western Blot: ATOH8 AntibodyBSA Free [NBP1-77347]

Western Blot: ATOH8 AntibodyBSA Free [NBP1-77347]

Western Blot: ATOH8 Antibody [NBP1-77347] - A-20 cell lysate with ATOH8 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry-Paraffin: ATOH8 Antibody - BSA Free [NBP1-77347]

Immunohistochemistry-Paraffin: ATOH8 Antibody - BSA Free [NBP1-77347]

Immunohistochemistry-Paraffin: ATOH8 Antibody [NBP1-77347] - Mouse brain tissue with ATOH8 antibody at 5 ug/ml.
ATOH8 Antibody - BSA Free

Immunohistochemistry: ATOH8 Antibody - BSA Free [NBP1-77347] -

Immunohistochemistry: ATOH8 Antibody - BSA Free [NBP1-77347] - Immunohistochemistry of ATOH8 in mouse brain tissue with ATOH8 antibody at 5 u/mL.
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Applications for ATOH8 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ATOH8

Basic helix-loop-helix (bHLH) transcription factors play important roles in differentiation processes during embryonic development of vertebrates. ATOH8 (MATH6) is a tissue-restricted member of the atonal superfamily of bHLH transcription factors that exhibits 43-57% identity in the bHLH domain with other mammalian atonal paralogs including the NeuroD and Neurogenin factors. In the mouse, ATOH8 has been implicated in the specification and differentiation of neuronal cell lineages in the brain and may also participate in kidney development. Recent studies show that ATOH8 is a novel component of the pancreatic transcriptional network during embryonic development and suggest a potential role as a modulator of the differentiation program initiated by the pro-endocrine factor Neurog3. It is indispensable for early embryonic development, suggesting a more widespread function for this factor in tissue-specific differentiation processes that are dependent on class II bHLH genes.

Alternate Names

ATH6, atonal homolog 6, atonal homolog 8 (Drosophila), basic helix-loop-helix transcription factor 6, BHLHA21, bHLHa21basic helix loop helix transcription factor 6, Class A basic helix-loop-helix protein 21, FLJ14708, FLJ38730, hATH6, Helix-loop-helix protein hATH-6, protein atonal homolog 8

Gene Symbol

ATOH8

UniProt

NP_116216 (Human)

Additional ATOH8 Products

Product Documents for ATOH8 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ATOH8 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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