B7-1/CD80 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-48954

Novus Biologicals, part of Bio-Techne
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NBP2-48954
NBP2-48954-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all B7-1/CD80 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: YECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENG

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for B7-1/CD80 Antibody - BSA Free

Immunohistochemistry-Paraffin: B7-1/CD80 Antibody [NBP2-48954]

Immunohistochemistry-Paraffin: B7-1/CD80 Antibody [NBP2-48954]

Immunohistochemistry-Paraffin: B7-1/CD80 Antibody [NBP2-48954] - Staining in human tonsil and pancreas tissues using anti-CD80 antibody. Corresponding CD80 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: B7-1/CD80 Antibody [NBP2-48954]

Immunohistochemistry-Paraffin: B7-1/CD80 Antibody [NBP2-48954]

Immunohistochemistry-Paraffin: B7-1/CD80 Antibody [NBP2-48954] - Staining of human tonsil shows high expression.
Immunohistochemistry-Paraffin: B7-1/CD80 Antibody [NBP2-48954]

Immunohistochemistry-Paraffin: B7-1/CD80 Antibody [NBP2-48954]

Immunohistochemistry-Paraffin: B7-1/CD80 Antibody [NBP2-48954] - Staining of human pancreas shows low expression as expected.

Applications for B7-1/CD80 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: B7-1/CD80

The B-lymphocyte activation antigen B7-1 (CD80) provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. After engagement of T-cell receptor with antigen in association with major histocompatibility complex class II, a second signal mediated through the binding of B7 to CD28 greatly upregulates the production of multiple lymphokines (1). The relatively small CTLA-4/B7-1 binding interface exhibits an unusually high degree of shape complementarity. CTLA-4 forms homodimers through a newly defined interface of highly conserved residues. This zipper-like oligomerization provides the structural basis for forming unusually stable signalling complexes at the T-cell surface, underscoring the importance of potent inhibitory signalling in human immune responses (2).

Alternate Names

B71, CD80

Gene Symbol

CD80

Additional B7-1/CD80 Products

Product Documents for B7-1/CD80 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for B7-1/CD80 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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