BACE-1 Antibody (SR2142)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21741

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21741-100ul
NBP3-21741-50ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2142

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all BACE-1 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human BACE-1 (Uniprot #: P56817)

Specificity

Detects endogenous levels of total BACE-1

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

70 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for BACE-1 Antibody (SR2142)

Western Blot: BACE-1 Antibody (SR2142) [NBP3-21741] -

Western Blot: BACE-1 Antibody (SR2142) [NBP3-21741] - Western blot analysis using NBP3-21741 in SH-SY5Y cell lysate.

Applications for BACE-1 Antibody (SR2142)

Application
Recommended Usage

Immunoprecipitation

1:40

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: BACE-1

BACE1 is a protease responsible for the proteolytic processing of the amyloid precursor protein (APP). Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimers disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE), of which there are two isoforms, BACE1 and 2. This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide.

Long Name

beta-site Ayloid Precursor Protein Cleaving Enzyme 1

Alternate Names

BACE1

Gene Symbol

BACE1

Additional BACE-1 Products

Product Documents for BACE-1 Antibody (SR2142)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for BACE-1 Antibody (SR2142)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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