BAF180/PB1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-90016

Novus Biologicals, part of Bio-Techne
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NBP1-90016
NBP1-90016-25ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Mouse (97%), Rat (96%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all BAF180/PB1 Antibodies »

Product Summary for BAF180/PB1 Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: KMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPAYLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHA

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for BAF180/PB1 Antibody

Immunohistochemistry-Paraffin: BAF180/PB1 Antibody [NBP1-90016]

Immunohistochemistry-Paraffin: BAF180/PB1 Antibody [NBP1-90016]

Immunohistochemistry-Paraffin: BAF180/PB1 Antibody [NBP1-90016] - Staining of human cerebral cortex shows moderate to strong nuclear positivity in neuronal cells.
Immunohistochemistry-Paraffin: BAF180/PB1 Antibody [NBP1-90016]

Immunohistochemistry-Paraffin: BAF180/PB1 Antibody [NBP1-90016]

Immunohistochemistry-Paraffin: BAF180/PB1 Antibody [NBP1-90016] - Staining of human renal cancer, clear cell carcinoma shows moderate nuclear positivity in tumor cells.
Immunohistochemistry-Paraffin: BAF180/PB1 Antibody [NBP1-90016]

Immunohistochemistry-Paraffin: BAF180/PB1 Antibody [NBP1-90016]

Immunohistochemistry-Paraffin: BAF180/PB1 Antibody [NBP1-90016] - Staining of human endometrium shows moderate to strong nuclear positivity in glandular cells.
View 1 more images

Applications for BAF180/PB1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: BAF180/PB1

The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. PB1/BAF180 is a component of the SWI/SNF-B (PBAF) complex. It contains six bromodomains which are defined by a 110 amino-acid module that interacts with acetylated lysine and is found in many chromatin binding proteins and histone acetyltransferases. PB1/BAF180 has been proposed to function as a tumor suppressor protein. Recently, PB1/BAF180 has been found to play a role in mediating cell cycle arrest in response to DNA damage via the regulation of the tumor suppressor p21. Alternate names for PB1/BAF180 include protein polybromo-1, polybromo-1D, BRG1-associated factor 180, hPB1, and PBRM1.

Long Name

Protein polybromo-1

Alternate Names

BAF180, hPB1, PB1, PBRM1, Polybromo-1D

Gene Symbol

PBRM1

Additional BAF180/PB1 Products

Product Documents for BAF180/PB1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for BAF180/PB1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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