BCAS2 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-77124

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all BCAS2 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human BCAS2. The immunogen is located within the last 50 amino acids of BCAS2. Amino Acid Squence: QHGEANKENIRQDF

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for BCAS2 Antibody - BSA Free

Western Blot: BCAS2 AntibodyBSA Free [NBP1-77124]

Western Blot: BCAS2 AntibodyBSA Free [NBP1-77124]

Western Blot: BCAS2 Antibody [NBP1-77124] - MCF7 cell lysate with BCAS2 antibody at (A) 0.5 and (B) 1 ug/ml.
Immunohistochemistry-Paraffin: BCAS2 Antibody - BSA Free [NBP1-77124]

Immunohistochemistry-Paraffin: BCAS2 Antibody - BSA Free [NBP1-77124]

Immunohistochemistry-Paraffin: BCAS2 Antibody [NBP1-77124] - Human breast carcinoma with BCAS2 antibody at 5 ug/mL.
Immunohistochemistry: BCAS2 Antibody - BSA Free [NBP1-77124]

Immunohistochemistry: BCAS2 Antibody - BSA Free [NBP1-77124]

Immunohistochemistry: BCAS2 Antibody [NBP1-77124] - Immunofluorescence of BCAS2 in human breast carcinoma tissue with BCAS2 antibody at 20 ug/mL.
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Applications for BCAS2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

0.5-1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: BCAS2

BCAS2 was identified through differential display analysis as an mRNA species that was overexpressed in MCF7 and BT-20 breast cancer cell lines. The chromosomal region containing this gene, 1p13.3021, is amplified in these cells lines. BCAS2 is a transcriptional cofactor that enhances estrogen receptor-mediated gene expression, and directly interacts with the tumor suppressor p53 to reduce p53 transcriptional activity by reducing p53 protein level in the absence of DNA damage. Deprivation of BCAS2 through RNA inhibition induces apoptosis in p53-wild type cells, but causes G2-M arrest in p53-null or -mutant cells; this effect was reversed with the expression of ectopic BCAS2. BCAS2 may thus be potentially useful as a therapeutic target in the treatment of cancer.

Alternate Names

breast carcinoma amplified sequence 2, Breast carcinoma-amplified sequence 2, DAM1DNA amplified in mammary carcinoma 1 protein, pre-mRNA-splicing factor SPF27, Snt309, SPF27, spliceosome associated protein, amplified in breast cancer, Spliceosome-associated protein SPF 27

Gene Symbol

BCAS2

UniProt

CAG46834 (Human)

Additional BCAS2 Products

Product Documents for BCAS2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for BCAS2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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