BCL11B Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-2600

Novus Biologicals, part of Bio-Techne
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NB100-2600
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Human, Mouse, Rat

Predicted:

Bovine (100%), Canine (100%), Chimpanzee (100%), Guinea Pig (100%), Monkey (100%), Orangutan (100%), Porcine (100%), Rabbit (100%), Xenopus (100%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin

Cited:

IF/IHC, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.25 mg/ml

View all BCL11B Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 850 and the C-terminus (residue 894) of human B-cell CLL/lymphoma 11B using the numbering given in Swiss-Prot entry Q9C0K0 (GeneID 64919).

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 26465886). Mouse reactivity reported from a verified customer review. Gorilla, X.tropicalis (100%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for BCL11B Antibody

Immunohistochemistry-Paraffin: BCL11B Antibody [NB100-2600]

Immunohistochemistry-Paraffin: BCL11B Antibody [NB100-2600]

Immunohistochemistry-Paraffin: BCL11B Antibody [NB100-2600] - Section of human skin tumor (higher magnification). Antibody: Affinity purified rabbit anti-Bcl11b used at a dilution of 1:500. Detection: DAB staining using anti-Rabbit IHC antibody at a dilution of 1:100.
Immunohistochemistry-Paraffin: BCL11B Antibody [NB100-2600]

Immunohistochemistry-Paraffin: BCL11B Antibody [NB100-2600]

Immunohistochemistry-Paraffin: BCL11B Antibody [NB100-2600] - P7 brain mouse section was stained with anti-BCL11B antibody. Image from verified customer review.
Immunohistochemistry: BCL11B Antibody [NB100-2600]

Immunohistochemistry: BCL11B Antibody [NB100-2600]

Immunohistochemistry: BCL11B Antibody [NB100-2600] - Immunohistochemistry and FISH of AML cases. Immunohistochemistry analysis of BCL11B-expressing AML samples #59810, #57863 and #13 carrying t(2;14)(q22.3;q32.3), t(7;14)(q21q32) and no 14q32 alteration, respectively. BCL11B expression was detected in samples regardless of the presence of the 14q32 alterations. The expression was limited to the nucleus and the percentage of positive neoplastic cells was always >= 50%. Image collected and cropped by CiteAb from the following publication (https://www.mdpi.com/2072-6694/11/12/1951), licensed under a CC-BY license.
View 1 more images

Applications for BCL11B Antibody

Application
Recommended Usage

Immunohistochemistry

1:100-1:500

Immunohistochemistry-Paraffin

1:100-1:500
Application Notes
Epitope exposure is recommended to enhance staining. ICC/IF reactivity reported in scientific literature (PMID: 24155294). IHC-F reactivity reported in scientific literature (PMID: 24155294). BCL11B antibody validated for IHC-P from a verified customer review.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Reviewed Applications

Read 1 review rated 5 using NB100-2600 in the following applications:

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.25 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: BCL11B

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development. NCOA6 is over-expressed in several breast cancer cell lines.

Alternate Names

B-cell CLL/lymphoma 11B, B-cell CLL/lymphoma 11B (zinc finger protein), B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion protein, B-cell lymphoma/leukaemia 11B, B-cell lymphoma/leukemia 11B, BCL-11B, BCL11B/TRDC fusion, COUP-TF-interacting protein 2, CTIP-2, CTIP2ZNF856B, hRit1, hRIT1-alpha, Radiation-induced tumor suppressor gene 1 protein, RIT1, zinc finger protein hRit1 alpha

Entrez Gene IDs

64919 (Human)

Gene Symbol

BCL11B

UniProt

Q9C0K0 (Human)

Additional BCL11B Products

Product Documents for BCL11B Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for BCL11B Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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