beta-TrCP1/BTRC Antibody (4C5D8) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-61712

Novus Biologicals, part of Bio-Techne
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NBP2-61712
NBP2-61712-0.025ml
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Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 4C5D8

Format

BSA Free

Concentration

1 mg/ml

View all beta-TrCP1/BTRC Antibodies »

Product Summary for beta-TrCP1/BTRC Antibody (4C5D8) - BSA Free

Immunogen

Purified recombinant fragment of human beta-TrCP1/BTRC (AA: 24-151) expressed in E. Coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

68.9 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for beta-TrCP1/BTRC Antibody (4C5D8) - BSA Free

Western Blot: beta-TrCP1/BTRC Antibody (4C5D8)BSA Free [NBP2-61712]

Western Blot: beta-TrCP1/BTRC Antibody (4C5D8)BSA Free [NBP2-61712]

Western Blot: beta-TrCP1/BTRC Antibody (4C5D8) [NBP2-61712] - Analysis using BTRC mAb against HEK293 (1) and BTRC (AA: 24-151)-hIgGFc transfected HEK293 (2) cell lysate.
Immunohistochemistry: beta-TrCP1/BTRC Antibody (4C5D8) - BSA Free [NBP2-61712]

Immunohistochemistry: beta-TrCP1/BTRC Antibody (4C5D8) - BSA Free [NBP2-61712]

Immunohistochemistry: beta-TrCP1/BTRC Antibody (4C5D8) [NBP2-61712] - Analysis of paraffin-embedded rectum cancer tissues using BTRC mouse mAb with DAB staining.
Flow Cytometry: beta-TrCP1/BTRC Antibody (4C5D8) - BSA Free [NBP2-61712]

Flow Cytometry: beta-TrCP1/BTRC Antibody (4C5D8) - BSA Free [NBP2-61712]

Flow Cytometry: beta-TrCP1/BTRC Antibody (4C5D8) [NBP2-61712] - Analysis of Hela cells using BTRC mouse mAb (green) and negative control (red).
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Applications for beta-TrCP1/BTRC Antibody (4C5D8) - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Flow Cytometry

1:10-1:1000

Immunohistochemistry

1:10-1:1000

Immunohistochemistry-Paraffin

1:200 - 1:1000

Western Blot

1:100-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: beta-TrCP1/BTRC

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.

Long Name

Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase

Alternate Names

betaTrCP1, BTRC, BTRCP, E3RSIkappaB, FBW1A, FBXW1A, FWD1

Gene Symbol

BTRC

Additional beta-TrCP1/BTRC Products

Product Documents for beta-TrCP1/BTRC Antibody (4C5D8) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for beta-TrCP1/BTRC Antibody (4C5D8) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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