Biliverdin Reductase A/BLVRA Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB120-3466

Novus Biologicals, part of Bio-Techne
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NB120-3466-0.025mg
NB120-3466
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Chicken IgY

Concentration

1 mg/ml

View all Biliverdin Reductase A/BLVRA Antibodies »

Product Specifications

Immunogen

Purified human biliverdin-IX alpha-reductase expressed in E. coli.

Specificity

NB120-3466 detects biliverdin-IX alpha reductase (BLVRA) from human cells.

Clonality

Polyclonal

Host

Chicken

Isotype

IgY

Scientific Data Images for Biliverdin Reductase A/BLVRA Antibody

Western Blot: Biliverdin Reductase A/BLVRA Antibody [NB120-3466]

Western Blot: Biliverdin Reductase A/BLVRA Antibody [NB120-3466]

Western Blot: Biliverdin Reductase A/BLVRA Antibody [NB120-3466] - Analysis of BLVRA on HeLa cell extract.

Applications for Biliverdin Reductase A/BLVRA Antibody

Application
Recommended Usage

Western Blot

0.1 ug/ml
Application Notes
WB: Detects an approx. 40 kDa protein representing BLVRA from HeLa cell extract.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Biliverdin Reductase A/BLVRA

Biliverdin Reductase (BLVR) is a ubiquitously expressed, small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The first step of this process is catalyzed by heme oxygenase, an enzyme that converts heme to iron, carbon monoxide, and biliverdin. BLVR is unique among all enzymes to date in being dual pH/dual cofactor-dependent, as it requires NADH (pH 6.7) or NADPH (pH 8.7) as an electron donor. There are two isoforms of BLVR, Biliverdin-IX alpha-reductase (BLVRA), the major component of human adult liver, and biliverdin IX beta-reductase (BLVRB), found predominantly in fetal liver. The product of BLVR, bilirubin, is an important biological antioxidant, however it is also a neurotoxin and the cause of kernicterus. In addition to being an antioxidant, it inhibits kinase activity and the activity of enzymes such as protein kinase C and NADPH oxidase.

Alternate Names

BLVRA, BVR, BVRA

Entrez Gene IDs

644 (Human)

Gene Symbol

BLVRA

Additional Biliverdin Reductase A/BLVRA Products

Product Documents for Biliverdin Reductase A/BLVRA Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Biliverdin Reductase A/BLVRA Antibody

Chicken products cannot be exported to Canada.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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