BIRC6 Antibody
Novus Biologicals, part of Bio-Techne | Catalog # NB110-40730
Key Product Details
Validated by
Biological Validation
Species Reactivity
Validated:
Human
Cited:
Human
Predicted:
Chimpanzee (100%), Monkey (100%), Orangutan (100%). Backed by our 100% Guarantee.
Applications
Validated:
Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot
Cited:
IF/IHC, Immunohistochemistry-Paraffin, Western Blot
Label
Unconjugated
Antibody Source
Polyclonal Rabbit IgG
Concentration
0.05 mg/ml
Product Specifications
Immunogen
The immunogen recognized by this antibody maps to a region between residues 4775 and the C-terminus (residue 4829) of human Baculoviral IAP repeat-containing protein 6 using the numbering given in Swiss-Prot entry Q9NR09 (GeneID 57448).
Reactivity Notes
Crab-eating macaque and White-tufted-ear marmoset (100%).
Clonality
Polyclonal
Host
Rabbit
Isotype
IgG
Scientific Data Images for BIRC6 Antibody
Western Blot: BIRC6 Antibody [NB110-40730]
Western Blot: BIRC6 Antibody [NB110-40730] - Dual IAP-targeting ASOs knockdown BIRC6, cIAP1 or survivin proteins and lead to marked suppression of CRPC cell proliferation. Western blotting showing protein levels of BIRC6, cIAP1 and survivin in two CRPC cell lines (A) PC-3 cells and (B) C4-2 cells transfected with Mock or increasing dosages of scrambled ASO (Scrb), dASOs 6w2 and 6w5 for 72 hr. Image collected and cropped by CiteAb from the following publication (https://www.oncotarget.com/fulltext/2229), licensed under a CC-BY license.Immunohistochemistry: BIRC6 Antibody [NB110-40730]
Immunohistochemistry: BIRC6 Antibody [NB110-40730] - Treatments with dASOs resulted in significant lower viable tumor volume. Representative images of control ASO-6w2- and 6w5-treated PC-3 xenografts using H&E, and IHC staining of BIRC6, cleaved-caspase 3 and Ki-67. 20x magnification. Image collected and cropped by CiteAb from the following publication (https://www.oncotarget.com/fulltext/2229), licensed under a CC-BY license.Immunohistochemistry-Paraffin: BIRC6 Antibody [NB110-40730]
Immunohistochemistry-Paraffin: BIRC6 Antibody [NB110-40730] - FFPE section of human metastatic lymph node. Antibody: Affinity purified rabbitanti-BIRC6/Apollon used at a dilution of 1:250. Detection: DABApplications for BIRC6 Antibody
Application
Recommended Usage
Immunohistochemistry
1:100-1:500
Immunohistochemistry-Paraffin
1:100-1:500
Western Blot
1:100-1:2000
Application Notes
Western Blot was reported in scientific literature (PMID: 25071009). Epitope exposure with citrate buffer will enhance staining. Likely to work with frozen sections.
Formulation, Preparation, and Storage
Purification
Immunogen affinity purified
Formulation
TBS and 0.1% BSA
Preservative
0.09% Sodium Azide
Concentration
0.05 mg/ml
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C. Do not freeze.
Background: BIRC6
Long Name
Baculoviral IAP repeat-containing protein 6
Alternate Names
APOLLON, BRUCE, EC 2.3.2.27, KIAA1289
Entrez Gene IDs
57448 (Human)
Gene Symbol
BIRC6
UniProt
Additional BIRC6 Products
Product Documents for BIRC6 Antibody
Product Specific Notices for BIRC6 Antibody
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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