BMPR-IB/ALK-6 Antibody (MM0055-3E12) [Janelia Fluor® 669]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-12031JF669

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Janelia Fluor 669

Antibody Source

Monoclonal Mouse IgG2 Clone # MM0055-3E12

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all BMPR-IB/ALK-6 Antibodies »

Product Specifications

Immunogen

Human recombinant BMPR-IB/ALK-6 (extracellular domain)

Specificity

In direct ELISAs and Western blots, 100% good cross-reactivity with recombinant mouse BMPR-IB, but no cross-reactivity with recombinant human and mouse BMPR-IA is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2

Applications for BMPR-IB/ALK-6 Antibody (MM0055-3E12) [Janelia Fluor® 669]

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: BMPR-IB/ALK-6

BMPR1B encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension.

Long Name

Bone Morphogenetic Protein Receptor IB

Alternate Names

ALK-6, BMPR1B, BMPRIB, CDw293

Gene Symbol

BMPR1B

Additional BMPR-IB/ALK-6 Products

Product Documents for BMPR-IB/ALK-6 Antibody (MM0055-3E12) [Janelia Fluor® 669]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for BMPR-IB/ALK-6 Antibody (MM0055-3E12) [Janelia Fluor® 669]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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