BNIP2 Antibody (8C6)

Novus Biologicals, part of Bio-Techne | Catalog # H00000663-M02-100ug

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 8C6

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all BNIP2 Antibodies »

Product Specifications

Immunogen

BNIP2 (AAH02461, 1 a.a. ~ 314 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MEGVELKEEWQDEDFPIPLPEDDSIEADILAITGPEDQPGSLEVNGNKVRKKLMAPDISLTLDPSDGSVLSDDLDESGEIDLDGLDTPSENSNEFEWEDDLPKPKTTEVIRKGSITEYTAAEEKEDGRRWRMFRIGEQDHRVDMKAIEPYKKVISHGGYYGDGLNAIVVFAVCFMPESSQPNYRYLMDNLFKYVIGTLELLVAENYMIVYLNGATTRRKMPSLGWLRKCYQQIDRRLRKNLKSLIIVHPSWFIRTLLAVTRPFISSKFSQKIRYVFNLAELAELVPMEYVGIPECIKQVDQELNGKQDEPKNEQ

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Scientific Data Images for BNIP2 Antibody (8C6)

Western Blot: BNIP2 Antibody (8C6) [H00000663-M02-100ug]

Western Blot: BNIP2 Antibody (8C6) [H00000663-M02-100ug]

Western Blot: BNIP2 Antibody (8C6) [H00000663-M02-100ug] - Analysis of BNIP2 expression in transfected 293T cell line by BNIP2 monoclonal antibody (M02), clone 8C6. Lane 1: BNIP2 transfected lysate (Predicted MW: 36 KDa). Lane 2: Non-transfected lysate.
Western Blot: BNIP2 Antibody (8C6) [H00000663-M02-100ug]

Western Blot: BNIP2 Antibody (8C6) [H00000663-M02-100ug]

Western Blot: BNIP2 Antibody (8C6) [H00000663-M02-100ug] - Analysis of BNIP2 expression in K-562.
ELISA: BNIP2 Antibody (8C6) [H00000663-M02-100ug]

ELISA: BNIP2 Antibody (8C6) [H00000663-M02-100ug]

ELISA: BNIP2 Antibody (8C6) [H00000663-M02-100ug] - Detection limit for recombinant GST tagged BNIP2 is 0.3 ng/ml as a capture antibody.

Applications for BNIP2 Antibody (8C6)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: BNIP2

The adenovirus E1B protein is a viral homolog of the Bcl-2 family of proteins that are involved in regulating cell death. A family of interacting proteins, which are designated Nip or Bnip and include BNIP-1, BNIP-2, BNIP-3 and Nix, associate with both the E1B protein and Bcl-2 proteins to mediate apoptotic signaling. BNIP-1 contains a hydrophobic transmembrane domain, which enables its localization to the nuclear envelope, endoplasmic recticulum and mitochondria. BNIP-2, (previously designated Nip2 and Nip21 in human and mouse respectively), shares homology with the non-catalytic domain of Cdc42 GTPase-activating protein (Cdc42GAP). Through binding to Cdc42GAP, BNIP-2 enhances the GTPase activity of Cdc42GAP, facilitating the hydrolysis of GTP bound to Cdc42 and thereby, mediating the signaling pathways involving receptor kinases, small GTPases and apoptotic proteins. Nix, which is also designated Nip3L or Bnip3L, is highly related to BNIP-3, and both proteins localize to the mitochondria where they associate with Bcl-2 proteins.

Alternate Names

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2, BCL2/adenovirus E1B 19kDa interacting protein 2, BCL2/adenovirus E1B 19kD-interacting protein 2, BNIP-2, NIP2

Entrez Gene IDs

663 (Human)

Gene Symbol

BNIP2

OMIM

603292 (Human)

UniProt

AAH02461 (Human)

Additional BNIP2 Products

Product Documents for BNIP2 Antibody (8C6)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for BNIP2 Antibody (8C6)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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