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BRCA2 Antibody (5F6)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-41189

Novus Biologicals, part of Bio-Techne
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NBP1-41189

Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 5F6

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Product Specifications

Immunogen

Amino acids 2336-2478 of human BRCA2 expressed in E. coli. BRCA2-P400.

Localization

Nuclear

Specificity

This antibody will recognize human BRCA2.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

384 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for BRCA2 Antibody (5F6)

BRCA2 Antibody (5F6)

Western Blot: BRCA2 Antibody (5F6) [NBP1-41189] -

Western Blot: BRCA2 Antibody (5F6) [NBP1-41189] - Whole cell extract (30 ug) was separated by 5% SDS-PAGE, and the membrane was blotted with BRCA2 antibody [5F6] diluted at 1:1000. The HRP-conjugated anti-mouse IgG antibody (NBP2-19382) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.

Applications for BRCA2 Antibody (5F6)

Application
Recommended Usage

Immunohistochemistry

1:10 - 1:500

Immunohistochemistry-Frozen

1:10 - 1:500

Immunohistochemistry-Paraffin

1:10 - 1:500

Western Blot

1-5 ug/ml
Application Notes
Do not boil samples for longer than two minutes.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: BRCA2

BRCA2-5F6 recognizes the BRCA2 gene product, a 390kDa nuclear protein. The BRCA2 gene was originally isolated based on its importance in the predisposition of women to early-onset breast and ovarian cancers, suggesting mutations affect its tumor suppressor-like activity. Targeted disruption of the BRCA2 gene in mice and binding of Rad51 to its carboxyl terminus have indicated an involvement in DNA recombination and double strand break repair.

Long Name

Breast Cancer 2

Alternate Names

BRCA1/BRCA2-containing complex, subunit 2, BRCC2, breast and ovarian cancer susceptibility gene, early onset, breast cancer 2 tumor suppressor, breast cancer 2, early onset, breast cancer susceptibility protein BRCA2, breast cancer type 2 susceptibility protein, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1Fanconi anemia, complementation group D1, Fanconi anemia group D1 protein, GLM3, PNCA2

Entrez Gene IDs

675 (Human)

Gene Symbol

BRCA2

UniProt

Additional BRCA2 Products

Product Documents for BRCA2 Antibody (5F6)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for BRCA2 Antibody (5F6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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