BubR1 Antibody (S05-3G7)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19840

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19840-100ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S05-3G7

Concentration

0.3 mg/ml

View all BubR1 Antibodies »

Product Specifications

Immunogen

A synthetic peptide of human BubR1 (Uniprot # O60566)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

120 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for BubR1 Antibody (S05-3G7)

Western Blot: BubR1 Antibody (S05-3G7) [NBP3-19840]

Western Blot: BubR1 Antibody (S05-3G7) [NBP3-19840]

Western Blot: BubR1 Antibody (S05-3G7) [NBP3-19840] - Western blot detection of BubR1 in CHO-K1, Ramos cell lysates using NBP3-19840 (1:1000 diluted). Predicted band size: 120kDa. Observed band size: 120kDa.
Immunohistochemistry-Paraffin: BubR1 Antibody (S05-3G7) [NBP3-19840]

Immunohistochemistry-Paraffin: BubR1 Antibody (S05-3G7) [NBP3-19840]

Immunohistochemistry-Paraffin: BubR1 Antibody (S05-3G7) [NBP3-19840] - Immunohistochemistry of BubR1 in paraffin-embedded Human lung cancer tissue using NBP3-19840 at dilution 1/50

Applications for BubR1 Antibody (S05-3G7)

Application
Recommended Usage

Immunohistochemistry

1/20

Western Blot

1/2000-1/10000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: BubR1

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B), also known as BubR1, is a kinase involved in spindle checkpoint function. BUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. BubR-1 localizes to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation.

BubR1 antibodies are useful tools for cancer research and cell division studies.

Alternate Names

Bub1A, BUBR1budding uninhibited by benzimidazoles 1 (yeast homolog), beta, budding uninhibited by benzimidazoles 1 homolog beta (yeast), EC 2.7.11.1, hBUBR1, MAD3/BUB1-related protein kinase, MAD3LBUB1beta, Mitotic checkpoint kinase MAD3L, Protein SSK1, SSK1mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Gene Symbol

BUB1B

Additional BubR1 Products

Product Documents for BubR1 Antibody (S05-3G7)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for BubR1 Antibody (S05-3G7)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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