c-jun Antibody (CL9662)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21172

Novus Biologicals, part of Bio-Techne
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NBP3-21172-100ul
NBP3-21172-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL9662

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all c-Jun Antibodies »

Product Summary for c-jun Antibody (CL9662)

Immunogen

This antibody was developed against a Synthetic Peptide of P05412. Actual immunogen sequence is proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for c-jun Antibody (CL9662)

Immunohistochemistry-Paraffin: c-jun Antibody [NBP3-21172] -

Immunohistochemistry-Paraffin: c-jun Antibody [NBP3-21172] -

Staining of human thyroid gland shows moderate nuclear positivity in glandular cells.
Immunohistochemistry-Paraffin: c-jun Antibody [NBP3-21172] -

Immunohistochemistry-Paraffin: c-jun Antibody [NBP3-21172] -

Staining of human endometrium shows strong nuclear positivity in glandular cells.
Immunohistochemistry-Paraffin: c-jun Antibody [NBP3-21172] -

Immunohistochemistry-Paraffin: c-jun Antibody [NBP3-21172] -

Staining of human colorectal cancer shows strong nuclear positivity in tumor cells.
View 2 more images

Applications for c-jun Antibody (CL9662)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

2-10 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
ICC/IF Fixation Permeabilization: Use PFA/Triton X-100. For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: c-Jun

The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.

Long Name

Cellular Repressor of E1A-stimulated Genes/Transcription Factor AP-1

Alternate Names

cJun, JUN

Gene Symbol

JUN

Additional c-Jun Products

Product Documents for c-jun Antibody (CL9662)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for c-jun Antibody (CL9662)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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