C-Reactive Protein/CRP Antibody (C6cc)

Novus Biologicals, part of Bio-Techne | Catalog # NB200-442

Novus Biologicals, part of Bio-Techne
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NB200-442-0.1mg
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Mouse

Applications

Validated:

ELISA, Immunoaffinity Purification, Immunoassay, Immunohistochemistry, Sandwich ELISA

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # C6cc

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all C-Reactive Protein/CRP Antibodies »

Product Specifications

Immunogen

Hybridoma clone has been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with Human CRP.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 27323407).

Localization

Secreted

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for C-Reactive Protein/CRP Antibody (C6cc)

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

1:10-1:500

Sandwich ELISA

1:100-1:2000
Application Notes
Human C-reactive protein immunodetection in direct ELISA, high sensitivity sandwich immunoassay, competitive immunoassays, turbidimetric assays, immunoaffinity purification, immunohistochemistry. Recommended pair for hsCRP sandwich immunoassay (capture-detection): NB600-1333 - NB200-442.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4)

Preservative

0.09% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: C-Reactive Protein/CRP

C Reactive Protein is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is a pentraxin (cyclic pentameric protein) compound of five identical nonglycosylated subunits of 206 amino acids each (m.w. 24 kDa), that are bound noncovalently to form the physiologic CRP molecule (m.w. 117.5 kDa). C Reactive Protein mediates activities associated with preimmune nonspecific host resistance. It is opsonic, an initiator of the classical complement cascade and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. Studies have revealed that among other markers of inflammation, CRP shows the strongest association with cardiovascular events. Many clinical studies demonstrated that coronary mortality among patients with unstable angina and elevated CRP is significantly higher comparing with the patients without elevated CRP. Measurements of C reactive protein (hsCRP) in the patients with ischemic heart disease provide a novel method for detecting individuals at high risk of plaque rupture.

Alternate Names

CRP

Entrez Gene IDs

1401 (Human)

Gene Symbol

CRP

UniProt

P02741

Additional C-Reactive Protein/CRP Products

Product Documents for C-Reactive Protein/CRP Antibody (C6cc)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for C-Reactive Protein/CRP Antibody (C6cc)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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