CA125/MUC16 Antibody (OV185-1)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-22564

Novus Biologicals, part of Bio-Techne
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NBP1-22564
NBP1-22564-0.1ml
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

Electron Microscopy

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # OV185-1

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all CA125/MUC16 Antibodies »

Product Specifications

Immunogen

Partially purified human mucin fraction from a pool of cancer tissues of patients with epithelial ovarian cancer.

Localization

Extracellular membrane

Specificity

This antibody reacts specifically with CA125 ovarian cancer antigen. Several studies have shown that CA125 is a useful tumor marker for ovarian epithelial malignancies. However, CA125 has been described in other neoplasms such as seminal vesicle and anaplastic lymphomas.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for CA125/MUC16 Antibody (OV185-1)

Immunohistochemistry-Paraffin: CA125/MUC16 Antibody (OV185-1) [NBP1-22564]

Immunohistochemistry-Paraffin: CA125/MUC16 Antibody (OV185-1) [NBP1-22564]

Immunohistochemistry-Paraffin: CA125/MUC16 Antibody (OV185-1) [NBP1-22564] - Formalin fixed paraffin embedded human ovarian cancer stained with CA125 antibody (NBP1-22564).

Applications for CA125/MUC16 Antibody (OV185-1)

Application
Recommended Usage

Immunohistochemistry

1:50-1:100

Immunohistochemistry-Paraffin

1:50-1:100
Application Notes
IHC-P: recommended pretreatment of EDTA buffer, pH 8.0. Recommended incubation time of 30 min at RT.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS (pH 7.4), 0.2% BSA, Tween-20

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: CA125/MUC16

MUC16 (CA125) is a serum marker that is used routinely in gynecologic practice to monitor patients with ovarian cancer. It is a mullerian duct differentiation antigen that is over expressed in epithelial ovarian cancer cells and secreted into the blood, although its expression is not entirely confined to ovarian cancer. Most biochemical studies have concluded that MUC16 is a high molecular mass glycoprotein, although estimates of its size range from 200 to 2000 kDa with smaller subunits being described by some investigators.

Long Name

Ovarian Cancer Antigen CA125

Alternate Names

MUC16

Gene Symbol

MUC16

UniProt

Q8WXI7

Additional CA125/MUC16 Products

Product Documents for CA125/MUC16 Antibody (OV185-1)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CA125/MUC16 Antibody (OV185-1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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