CACNA1S Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-33799

Novus Biologicals, part of Bio-Techne
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NBP2-33799
NBP2-33799-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (91%), Rat (96%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CACNA1S Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: EEEKSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPEIPLSPRPRPLAEL

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CACNA1S Antibody

Immunohistochemistry-Paraffin: CACNA1S Antibody [NBP2-33799]

Immunohistochemistry-Paraffin: CACNA1S Antibody [NBP2-33799]

Immunohistochemistry-Paraffin: CACNA1S Antibody [NBP2-33799] - Staining in human skeletal muscle and heart muscle tissues using anti-CACNA1S antibody. Corresponding CACNA1S RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: CACNA1S Antibody [NBP2-33799]

Immunohistochemistry-Paraffin: CACNA1S Antibody [NBP2-33799]

Immunohistochemistry-Paraffin: CACNA1S Antibody [NBP2-33799] - Staining of human heart muscle shows low expression as expected.
Immunohistochemistry-Paraffin: CACNA1S Antibody [NBP2-33799]

Immunohistochemistry-Paraffin: CACNA1S Antibody [NBP2-33799]

Immunohistochemistry-Paraffin: CACNA1S Antibody [NBP2-33799] - Staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes.

Applications for CACNA1S Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CACNA1S

Voltage-sensitive calcium channels mediate the entry of calcium into many types of excitable cells and thus play a key role in neurotransmitter release and excitation-contraction (E-C) coupling. The 1,4-dihydropyridines (DHPs) are synthetic organic compounds which can be used to identify the L-type calcium channels that are found in all types of vertebrate muscle, neuronal and neuroendocrine cells. The DHP receptor is part of the L-type calcium channel complex and is thought to be the voltage sensor in E-C coupling.The purified DHP receptor isolated from triads is composed of at least four subunits. The alpha-1 subunit contains the binding site for the DHPs and shows high sequence homology to the voltage gated sodium channel. The alpha-2 subunit is a large glycoprotein associated with the DHP receptor which was first described in skeletal muscle and is also found in high concentrations in other excitable tissues such as cardiac muscle and brain and in low concentrations in most other tissues studied. The other two subunits that co-purify with the DHP receptor are termed beta and gamma.

Long Name

Voltage-dependent L-type calcium channel subunit alpha-1S

Alternate Names

CACH1, CACN1, CACNL1A3, Cav1.1, MHS5

Gene Symbol

CACNA1S

UniProt

Q13698 (Human)

Additional CACNA1S Products

Product Documents for CACNA1S Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CACNA1S Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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