Calcineurin A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-33041

Novus Biologicals, part of Bio-Techne
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NBP1-33041
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Bovine (100%), Canine (100%), Porcine (99%), Rabbit (100%), Rhesus Macaque (100%), Xenopus (98%), Zebrafish (93%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Calcineurin A Antibodies »

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the center region of human Calcineurin A. The exact sequence is proprietary.

Reactivity Notes

Xenopus laevis (98%).

Localization

Nucleus

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

59 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Calcineurin A Antibody

Immunocytochemistry/ Immunofluorescence: Calcineurin A Antibody [NBP1-33041]

Immunocytochemistry/ Immunofluorescence: Calcineurin A Antibody [NBP1-33041]

Immunocytochemistry/Immunofluorescence: Calcineurin A Antibody [NBP1-33041] - DIV9 rat E18 primary cortical neuron cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Calcineurin A stained by Calcineurin A antibody diluted at 1:500.Red: beta Tubulin 3/ Tuj1, stained by beta Tubulin 3/ Tuj1 antibody [1338] diluted at 1:500. Blue: Fluoroshield with DAPI.
Immunohistochemistry-Paraffin: Calcineurin A Antibody [NBP1-33041]

Immunohistochemistry-Paraffin: Calcineurin A Antibody [NBP1-33041]

Immunohistochemistry-Paraffin: Calcineurin A Antibody [NBP1-33041] - Paraffin-embedded human breast carcinoma dilution: 1:500.
Calcineurin A Antibody

Western Blot: Calcineurin A Antibody [NBP1-33041] -

Western Blot: Calcineurin A Antibody [NBP1-33041] - Various tissue extracts (50 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with Calcineurin A antibody (NBP1-33041) diluted at 1:1000.
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Applications for Calcineurin A Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100-1:1000

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:3000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS (pH 7), 20% Glycerol

Preservative

0.025% Proclin 300

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Calcineurin A

Calcineurin, a major soluble calmodulin binding protein in the brain, a Ca2+/calmodulin dependent serine/threonine protein phosphatase, with a relatively narrow substrate specificity. This metalloenzyme, also known as phosphatase 2B, is a heterodimer composed of a calmodulin binding, catalytic alpha subunit 61 kDa, calcineurin A) and calcium binding beta subunit (18 kDa, calcineurin B). The Ca2+ binding subunit, calcineurin B, is immunologically conserved from yeast to mammals. The presence of 2 different calcineurin B isoforms (beta 1 and beta 2) has been reported in rat testis. The catalytic subunit of calcineurin, calcineurin A, isolated from different tissues or different organisms, exhibits some immunological heterogeneity. Further, there are at least 2 isoforms of calcineurin A in bovine brain (alpha 1 and alpha 2, 61 and 59 kDa, respectively).

Alternate Names

CALNA, CNA1, PP2B, PP3CA, PPP2B, PPP3CA

Gene Symbol

PPP3CA

Additional Calcineurin A Products

Product Documents for Calcineurin A Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Calcineurin A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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