Calcitonin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB600-1156

Novus Biologicals, part of Bio-Techne
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NB600-1156
NB600-1156-25ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Gerbil, Rabbit

Cited:

Gerbil

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

IF/IHC, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Sheep

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Calcitonin Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to a portion of rat alpha-calcitonin gene-related peptide (CGRP).

Reactivity Notes

Gerbil reactivity reported in scientific literature (PMID: 21491428). Likely to react with other mammalian species (based on homology, not tested).

Localization

Secreted

Clonality

Polyclonal

Host

Sheep

Applications for Calcitonin Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:200-1:4000
Application Notes
Use in WB and ICC/IF reported in scientific literature (PMID: 21491428). Test tissues: Rat thoracolumbar spinal cord. Fixatives: Recommended fixative is 4% formaldehyde (prepared from para-polymer) in 0.1M sodium phosphate buffer (pH 7.2-7.4). Perfusion fixation is recommended if possible.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

PBS

Preservative

0.1% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Calcitonin

CGRP is present in C-cells of the thyroid and in central and peripheral nerves. CGRP has several important physiologic roles: it is a potent vasodilator, and can affect the force and rate of heart beat; it can modulate acetylcholine receptor function at the neuromuscular junction; it has been demonstrated to block tolerance to morphine; and it can modulate antigen presentation in Langerhans cells in the skin. Despite these important physiologic functions, therapeutic strategies using CGRP have been impeded due to the lack of a cloned CGRP receptor with which ligands could be developed.

Long Name

Calcitonin Related Polypeptide Alpha

Alternate Names

CALC1, CALCA, Katacalcin, PCT

Entrez Gene IDs

796 (Human); 291440 (Rat)

Gene Symbol

CALCA

UniProt

P01257 (Rat)

Additional Calcitonin Products

Product Documents for Calcitonin Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Calcitonin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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