Caldesmon/CALD1 Antibody (RM396)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-23459

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-23459
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM396

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Caldesmon/CALD1 Antibodies »

Product Summary for Caldesmon/CALD1 Antibody (RM396)

Immunogen

A peptide corresponding to human Caldesmon/CALD1 (Uniprot#: Q05682)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Caldesmon/CALD1 Antibody (RM396)

Caldesmon/CALD1 Antibody (RM396)

Western Blot: Caldesmon/CALD1 Antibody (RM396) [NBP3-23459] -

Western Blot: Caldesmon/CALD1 Antibody (RM396) [NBP3-23459] - Western Blot of HeLa cells lysate using Clone RM396) at a 1:100 dilution.
Caldesmon/CALD1 Antibody (RM396)

Immunohistochemistry-Paraffin: Caldesmon/CALD1 Antibody (RM396) [NBP3-23459] -

Immunohistochemistry-Paraffin: Caldesmon/CALD1 Antibody (RM396) [NBP3-23459] - Immunohistochemical staining of formalin fixed and paraffin embedded human colon tissue section using Clone RM396) at a 1:100 dilution.

Applications for Caldesmon/CALD1 Antibody (RM396)

Application
Recommended Usage

Immunohistochemistry

1:100-1:200

Western Blot

1:100-1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Caldesmon/CALD1

Caldesmon is a smooth muscle and nonmuscle regulatory protein that interacts with actin, myosin, tropomyosin, and calmodulin (1,2). Smooth muscle caldesmon is an elongated molecule with a calmodulin, tropomyosin, and actin-binding region at the C-terminus and a myosin-binding domain at the N-terminus (3). Caldesmon stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, caldesmon inhibits the actomyosin ATPase by binding to F-actin. This inhibition is reduced by calcium-calmodulin and is promoted by tropomyosin (4).

Alternate Names

CALD1, CDM, HCAD, LCAD, NAG22

Gene Symbol

CALD1

Additional Caldesmon/CALD1 Products

Product Documents for Caldesmon/CALD1 Antibody (RM396)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Caldesmon/CALD1 Antibody (RM396)

[Public Notes]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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