CaMKIV Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB120-3557

Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NB120-3557
NB120-3557-0.025mg
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Canine, Plant, Primate, Xenopus

Applications

Immunohistochemistry, Immunohistochemistry-Frozen, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all CaMKIV Antibodies »

Product Summary for CaMKIV Antibody

Immunogen

Synthetic Peptide: V(127) E K G Y Y S E R D A A D A V K Q(143) C

Localization

Cytoplasmic and Nuclear

Specificity

NB120-3557 detects CaM kinase IV (CaMKIV) from human, mouse, rat, canine, primate, arabidopsis and Xenopus Oocyte samples.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CaMKIV Antibody

Western Blot: CaMKIV Antibody [NB120-3557]

Western Blot: CaMKIV Antibody [NB120-3557]

Western Blot: CaMKIV Antibody [NB120-3557] - Analysis of rat brain extract.

Applications for CaMKIV Antibody

Application
Recommended Usage

Immunohistochemistry

1:10 - 1:500

Immunohistochemistry-Frozen

1 ug/ml

Western Blot

0.5 ug/ml
Application Notes
WB: Detects an approx. 55 kDa protein representing CaMKIV in HeLa cell lysate.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: CaMKIV

CaM kinase IV (CaMKIV), in a calcium and calmodulin dependent manner, is implicated in phosphorylating numerous transcription factors including the CCAAT enhancer binding protein (C / EBP), serum response factor (SRF), and cyclic AMP response element binding protein (CBP). The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression. CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees. In neurons, CaMKIV is thought to play an important role in synaptic plasticity via its gene regulatory effects. In T-cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T-cells (NFAT). CaMKIV is encoded, along with calspermin, by the CaMKIV gene. It has been found that, in testes, CaMKIV is expressed in germ cells and found to be associated with chromatin. The association of CaMKIV with chromatin suggests a potential role in chromatin remodeling during nuclear condensation in spermatids.

Alternate Names

brain Ca(2+)-calmodulin-dependent protein kinase type IV, brain Ca++-calmodulin-dependent protein kinase type IV, calcium/calmodulin-dependent protein kinase IV, calcium/calmodulin-dependent protein kinase type IV, calcium/calmodulin-dependent protein kinase type IV catalytic chain, CAM kinase- GR, CAM kinase IV, CaM kinase-GR, caMK, CaMK IV, CaMK-GR, EC 2.7.11, EC 2.7.11.17, IV, MGC36771

Entrez Gene IDs

814 (Human); 12326 (Mouse); 25050 (Rat)

Gene Symbol

CAMK4

Additional CaMKIV Products

Product Documents for CaMKIV Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for CaMKIV Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.