CAR/NR1I3 Antibody (OTI1C6) [HRP]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-71525H

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

HRP

Antibody Source

Monoclonal Mouse IgG1 Clone # OTI1C6

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all CAR/NR1I3 Antibodies »

Product Specifications

Immunogen

Recombinant protein fragment corresponding to amino acids 1-236 of human CAR/NR1I3 (NP_001070950) produced in E.coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for CAR/NR1I3 Antibody (OTI1C6) [HRP]

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: CAR/NR1I3

NR1I3 encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.

Long Name

Constitutive Androstane Receptor

Alternate Names

MB67, NR1I3

Gene Symbol

NR1I3

Additional CAR/NR1I3 Products

Product Documents for CAR/NR1I3 Antibody (OTI1C6) [HRP]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for CAR/NR1I3 Antibody (OTI1C6) [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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