CASK Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB300-321

Novus Biologicals, part of Bio-Techne
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NB300-321
NB300-321-0.025mg
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all CASK Antibodies »

Product Summary for CASK Antibody

Immunogen

Synthetic Peptide: C(578) E R D S P S T S R Q S P A N(592)

Epitope

The epitope lies between amino acid residues 578-592 from human CASK.

Localization

Cytoplasmic (Potential).

Specificity

By Western blot, this detects a 112 kDa protein representing CASK from AtT20 cell lysate. Immunohistochemical staining of CASK in mouse brain with this results in staining of the choroid plexus.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CASK Antibody

Western Blot: CASK Antibody [NB300-321]

Western Blot: CASK Antibody [NB300-321]

Western Blot: CASK Antibody [NB300-321] - Analysis of AtT20 cell lysate.

Applications for CASK Antibody

Application
Recommended Usage

Immunohistochemistry

1:10 - 1:500

Immunohistochemistry-Frozen

1:10 - 1:500

Immunohistochemistry-Paraffin

1:10 - 1:500

Western Blot

1 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: CASK

Calmodulin sensitive kinase (CASK/mLIN-2) is a ~112-kDa member of the membrane associated quanylate kinase (MAGUK) protein family with multiple protein binding domains. These include an N-terminal calmodulin kinase (CaMKII) domain and C-terminal PDZ, SH3-, and quanylate kinase domains. CASK possesses both tyrosine kinase and serine/threonine kinase activity. In addition, CASK can form a heterotrimeric complex with Mint (X11or mLIN-10) and Veli (mLIN-7) proteins which is predicted to participate in plasma membrane receptor localization. CASK is localized to neuronal synapses and also interacts with syndecan and neurexin. The guanylate kinase domain of CASK has been shown to interact with the T-box transcription factor, Tbr-1, as a coactivator to induce transcription of genes that contain T-elements.

Alternate Names

Calcium/calmodulin-dependent serine protein kinase, calcium/calmodulin-dependent serine protein kinase (MAGUK family), calcium/calmodulin-dependent serine protein kinase membrane-associatedguanylate kinase, CAMGUK, CMG, EC 2.7.11, EC 2.7.11.1, FGS4CAGH39, FLJ22219, hCASK, LIN2FLJ31914, MICPCH, peripheral plasma membrane protein CASK, Protein lin-2 homolog, TNRC8, trinucleotide repeat containing 8

Entrez Gene IDs

8573 (Human); 12361 (Mouse); 29647 (Rat)

Gene Symbol

CASK

Additional CASK Products

Product Documents for CASK Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CASK Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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