Caspase-2 Antibody (4-1-5)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-19194

Novus Biologicals, part of Bio-Techne
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NBP1-19194-0.05mg
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 4-1-5

Concentration

1.0 mg/ml

View all Caspase-2 Antibodies »

Product Specifications

Immunogen

Recombinant full length human Caspase-2

Specificity

Caspase-2 (4-1-5)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Caspase-2 Antibody (4-1-5)

Western Blot: Caspase-2 Antibody (4-1-5) [NBP1-19194]

Western Blot: Caspase-2 Antibody (4-1-5) [NBP1-19194]

Western Blot: Caspase-2 Antibody [NBP1-19194] - MW marker (1), Jurkat (2) and Jurkat + staurosporine (3) probed with Caspase 2 Monoclonal Antibody (4-1-5)

Applications for Caspase-2 Antibody (4-1-5)

Application
Recommended Usage

Western Blot

1:100-1:2000

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS, pH 7.2 and 50% glycerol.

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Caspase-2

Caspase-2 (Nedd2/ICH-1) is part of a family of aspartate-specific cysteine proteases that participate in programmed cell death, or apoptosis. Caspase-2 is localized to the nucleus, and has been shown to play roles in both positive and negative regulation of apoptosis (1). Upon apoptotic stimulation, pro-caspase-9 is cleaved in a series of steps to produce an 18-kDa large subunit and a 12-kDa small fragment (2). Caspase-2 can be a nuclear initiator caspase, as it has been shown to precede the processing and activation of caspase-8, -9, and -3 (3). Caspase-2 might also act as an effector caspase; in apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of caspase-9 and caspase-3 activation (4).

Alternate Names

CASP2, Caspase2, ICH-1, NEDD2

Entrez Gene IDs

835 (Human)

Gene Symbol

CASP2

Additional Caspase-2 Products

Product Documents for Caspase-2 Antibody (4-1-5)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Caspase-2 Antibody (4-1-5)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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