Caspase-6 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-87683

Novus Biologicals, part of Bio-Techne
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NBP1-87683
NBP1-87683-25ul
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Validated:

Human

Predicted:

Mouse (91%), Rat (91%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Caspase-6 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: DVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQV

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Caspase-6 Antibody

Immunohistochemistry-Paraffin: Caspase-6 Antibody [NBP1-87683]

Immunohistochemistry-Paraffin: Caspase-6 Antibody [NBP1-87683]

Immunohistochemistry-Paraffin: Caspase-6 Antibody [NBP1-87683] - Staining in human small intestine and skeletal muscle tissues using anti-CASP6 antibody. Corresponding CASP6 RNA-seq data are presented for the same tissues.
Western Blot: Caspase-6 Antibody [NBP1-87683]

Western Blot: Caspase-6 Antibody [NBP1-87683]

Western Blot: Caspase-6 Antibody [NBP1-87683] - Analysis using Anti-CASP6 antibody NBP1-87683 (A) shows similar pattern to independent antibody NBP1-87684 (B).
Immunohistochemistry-Paraffin: Caspase-6 Antibody [NBP1-87683]

Immunohistochemistry-Paraffin: Caspase-6 Antibody [NBP1-87683]

Immunohistochemistry-Paraffin: Caspase-6 Antibody [NBP1-87683] - Staining of human skeletal muscle shows low expression as expected.
View 2 more images

Applications for Caspase-6 Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Caspase-6

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-6 is a major apoptotic executioner (1,2). It exists as a pro-domain protein and is cleaved by caspase-3 into two active subunits, an 18 kDa and a 10 kDa subunit (3). Caspase-6 cleaves among many different intracellular proteins, nuclear lamins. Lamins play a significant role in maintaining the integrity of the cell membrane, and their cleavage results in subsequent cellular breakdown and death (4).

Alternate Names

CASP6, Caspase6, Mch2

Gene Symbol

CASP6

Additional Caspase-6 Products

Product Documents for Caspase-6 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Caspase-6 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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