Caspr1 Antibody (8O5H6)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-16262

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-16262-100ul
NBP3-16262-20ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 8O5H6

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Caspr1 Antibodies »

Product Specifications

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 700-800 of human Caspr11 (P78357). EQHFYWGGSQPGIQRCACGLDRSCVDPALYCNCDADQPQWRTDKGLLTFVDHLPVTQVVIGDTNRSTSEAQFFLRPLRCYGDRNSWNTISFHTGAALRFPP

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Caspr1 Antibody (8O5H6)

Western Blot: Caspr1 Antibody (8O5H6) [NBP3-16262]

Western Blot: Caspr1 Antibody (8O5H6) [NBP3-16262]

Western Blot: Caspr1 Antibody (8O5H6) [NBP3-16262] - Western blot analysis of extracts of U-87MG cells, using Caspr11 Rabbit mAb (NBP3-16262) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3s.

Applications for Caspr1 Antibody (8O5H6)

Application
Recommended Usage

Western Blot

1:500 - 1:1000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 0.05% BSA, 50% glycerol, pH7.3

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Caspr1

Contactin-associated protein 1 (Caspr1), also known as Neurexin-4, Paranodin, and NCP1, is an approximately 190 kDa transmembrane protein that is concentrated at paranodal junctions of axons during myelination. It is required for junction formation and ion channel localization and plays an important role in the propagation of saltatory nerve conduction. Caspr1 interacts with Contactins and Nogo-A at the paranodal junction and inhibits the binding of Contactin to glial cell Neurofascin. Caspr1 is proteolytically cleaved by Reelin, and this action is inhibited by the cellular prion protein (PrP). The ECD contains one Factor 5/8-like domain, four Laminin-G-like domains, two EGF-like domains, and one Fibrinogen-like domain.

Long Name

Contactin Associated Protein-like 1

Alternate Names

CNTNAP, CNTNAP1, p190

Gene Symbol

CNTNAP1

Additional Caspr1 Products

Product Documents for Caspr1 Antibody (8O5H6)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Caspr1 Antibody (8O5H6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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