Caspr1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-88183

Novus Biologicals, part of Bio-Techne
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NBP1-88183
NBP1-88183-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (96%), Rat (96%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Caspr1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: MRLNGVTLNLEGRANASEGTSPNCTGHCAHPRLPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFEPGTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYIPGYDTPGY

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Caspr1 Antibody

Immunocytochemistry/ Immunofluorescence: Caspr1 Antibody [NBP1-88183]

Immunocytochemistry/ Immunofluorescence: Caspr1 Antibody [NBP1-88183]

Immunocytochemistry/Immunofluorescence: Caspr1 Antibody [NBP1-88183] - Staining of human cell line HeLa shows localization to nucleoplasm. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Caspr1 Antibody [NBP1-88183]

Immunohistochemistry-Paraffin: Caspr1 Antibody [NBP1-88183]

Immunohistochemistry-Paraffin: Caspr1 Antibody [NBP1-88183] - Staining of human cerebral cortex shows strong cytoplasmic and nucleolar positivity in subset of neuronal cells, neuropil was distinctly stained.

Applications for Caspr1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Caspr1

Contactin-associated protein 1 (Caspr1), also known as Neurexin-4, Paranodin, and NCP1, is an approximately 190 kDa transmembrane protein that is concentrated at paranodal junctions of axons during myelination. It is required for junction formation and ion channel localization and plays an important role in the propagation of saltatory nerve conduction. Caspr1 interacts with Contactins and Nogo-A at the paranodal junction and inhibits the binding of Contactin to glial cell Neurofascin. Caspr1 is proteolytically cleaved by Reelin, and this action is inhibited by the cellular prion protein (PrP). The ECD contains one Factor 5/8-like domain, four Laminin-G-like domains, two EGF-like domains, and one Fibrinogen-like domain.

Long Name

Contactin Associated Protein-like 1

Alternate Names

CNTNAP, CNTNAP1, p190

Entrez Gene IDs

8506 (Human)

Gene Symbol

CNTNAP1

UniProt

P78357 (Human)

Additional Caspr1 Products

Product Documents for Caspr1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Caspr1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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