Cav1.3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-86684

Novus Biologicals, part of Bio-Techne
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NBP1-86684
NBP1-86684-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Cav1.3 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: EDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAV

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (87%), Rat (85%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Cav1.3 Antibody

Immunocytochemistry/ Immunofluorescence: Cav1.3 Antibody [NBP1-86684]

Immunocytochemistry/ Immunofluorescence: Cav1.3 Antibody [NBP1-86684]

Immunocytochemistry/Immunofluorescence: Cav1.3 Antibody [NBP1-86684] - Staining of human cell line CACO-2 shows localization to nuclear membrane. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Cav1.3 Antibody [NBP1-86684]

Immunohistochemistry-Paraffin: Cav1.3 Antibody [NBP1-86684]

Immunohistochemistry-Paraffin: Cav1.3 Antibody [NBP1-86684] - Staining of human kidney shows strong cytoplasmic positivity in cells in tubules.
Cav1.3 Antibody

Immunohistochemistry-Paraffin: Cav1.3 Antibody [NBP1-86684] -

Immunohistochemistry-Paraffin: Cav1.3 Antibody [NBP1-86684] - Staining of human small intestine shows strong cytoplasmic positivity in glandular cells.
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Applications for Cav1.3 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF, Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Cav1.3

Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).; Subcellular location: Membrane; Multi-pass membrane protein.; Tissue specificity: Expressed in pancreatic islets and in brain, where it has been seen in hippocampus, basal ganglia, habenula and thalamus. No expression in skeletal muscle.

Long Name

Voltage-dependent L-type calcium channel subunit alpha-1D

Alternate Names

CACH3, CACN4, CACNA1D, CACNL1A2, CCHL1A2

Gene Symbol

CACNA1D

Additional Cav1.3 Products

Product Documents for Cav1.3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Cav1.3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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