CBX1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-24706

Novus Biologicals, part of Bio-Techne
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NBP3-24706
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CBX1 Antibodies »

Product Summary for CBX1 Antibody

Immunogen

This antibody has been engineered to specifically recognize the recombinant protein CBX1 using the following amino acid sequence: ERLTWHSYPSEDDDKKDDKN

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CBX1 Antibody

CBX1 Antibody Immunocytochemistry/Immunofluorescence: CBX1 Antibody [NBP3-24706]

Immunocytochemistry/Immunofluorescence: CBX1 Antibody [NBP3-24706]

Staining of human cell line U2OS shows localization to nucleoplasm & nuclear bodies.
CBX1 Antibody Western Blot: CBX1 Antibody [NBP3-24706]

Western Blot: CBX1 Antibody [NBP3-24706]

Analysis in human cell line RT-4 and human cell line U-251 MG.

Applications for CBX1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 µg/ml

Western Blot

0.04-0.4 µg/ml
Application Notes
For ICC/IF, we recommend using a combination of PFA and Triton X-100. This will give you the optimal results for your experiments.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CBX1

HP1 gamma appears to be involved in transcriptional silencing in heterochromatin-like complexes. It recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. HP1 gamma may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) and involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Alternate Names

CBXM31HP1-BETA, chromobox homolog 1, chromobox homolog 1 (Drosophila HP1 beta), chromobox homolog 1 (HP1 beta homolog Drosophila ), chromobox protein homolog 1, Heterochromatin protein 1 homolog beta, heterochromatin protein 1-beta, Heterochromatin protein p25, heterochromatin protein p25 beta, HP1 beta, HP1 beta homolog, HP1Hsbeta, HP1Hs-beta, MOD1, Modifier 1 protein, p25beta

Gene Symbol

CBX1

Additional CBX1 Products

Product Documents for CBX1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CBX1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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