CBX4 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-81972

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all CBX4 Antibodies »

Product Specifications

Immunogen

CBX4 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CBX4. The immunogen is located within amino acids 50 - 100 of CBX4. Amino Acid Squence: EQLMGYRKRGPKPKPLV

Specificity

Two alternatively spliced transcript variants have been observed.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

62 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for CBX4 Antibody - BSA Free

Western Blot: CBX4 AntibodyBSA Free [NBP2-81972]

Western Blot: CBX4 AntibodyBSA Free [NBP2-81972]

Western Blot: CBX4 Antibody [NBP2-81972] - Analysis of CBX4 in human brain tissue lysate with CBX4 antibody at 1 ug/ml in the (A) absence and (B) presence of blocking peptide.
Immunocytochemistry/ Immunofluorescence: CBX4 Antibody - BSA Free [NBP2-81972]

Immunocytochemistry/ Immunofluorescence: CBX4 Antibody - BSA Free [NBP2-81972]

Immunocytochemistry/Immunofluorescence: CBX4 Antibody [NBP2-81972] - Analysis of CBX4 in human brain tissue with CBX4 antibody at 20 ug/ml.
CBX4 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: CBX4 Antibody - BSA Free [NBP2-81972] -

Immunocytochemistry/ Immunofluorescence: CBX4 Antibody - BSA Free [NBP2-81972] - Immunofluorescence of CBX4 in human brain tissue with CBX4 antibody at 20 u/mL.
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Applications for CBX4 Antibody - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CBX4

PC2 is the human homolog of the Drosophila 'Polycomb' (Pc) protein which has been identified as a gene family member associated with a cellular memory system that is responsible for the inheritance of gene activity by progeny cells. The human Pc homolog gene is more closely related to a Xenopus Pc homolog, XPc, than to a previously described human Pc homolog, CBX2 (hPc1). However, the hPc2 and CBX2/hPc1 proteins are shown to colocalize in interphase nuclei of human U-2 OS osteosarcoma cells, suggesting that the proteins are part of a common protein complex. The human protein is believed to function as a repressor of proto-oncogene activity and that interference with hPc2 function can lead to derepression of proto-oncogene transcription and subsequently to cellular transformation. Other reports describe PC2 as a protein that has SUMO E3 activity for the corepressors CtBP and CtBP2.

Alternate Names

chromobox homolog 4, chromobox homolog 4 (Drosophila Pc class), Chromobox protein homolog 4, Drosophila), E3 SUMO-protein ligase CBX4, hPc2, NS5ATP1-binding protein 16, Pc class 2 homolog, PC2, Polycomb 2 homolog

Gene Symbol

CBX4

Additional CBX4 Products

Product Documents for CBX4 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CBX4 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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