Ccd1/DIXDC1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-46147

Novus Biologicals, part of Bio-Techne
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NBP1-46147
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all Ccd1/DIXDC1 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-DVSYHQVDLERE corresponding to internal region according to NP_219493.1.

Epitope

internal region

Specificity

This antibody is expected to recognize both isoforms (NP_001033043.1; NP_219493.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Ccd1/DIXDC1 Antibody

Western Blot: Ccd1/DIXDC1 Antibody [NBP1-46147]

Western Blot: Ccd1/DIXDC1 Antibody [NBP1-46147]

Western Blot: Ccd1/DIXDC1 Antibody [NBP1-46147] - NBP1-46147 (0.5ug/ml) staining of Human Skeletal Muscle lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for Ccd1/DIXDC1 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:64000

Western Blot

0.5 - 2 ug/ml
Application Notes
WB: Approx. 60 kDa band observed in human heart and skeletal muscle lysates (calculated MW of 53.9 kDa band according to NP_219493.1).
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Ccd1/DIXDC1

DIXDC1 (DIX domain containing 1/Dixin) is a 683 amino acid protein. It positively regulates the Wnt signaling pathway by activating WNT3A via DVL2. It is expressed ubiquitously but has higher expression in skeletal and cardiac muscle. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation. DIXDC1 may play a role in breast cancer, breast carcinoma, endometrial cancer, epithelial neoplasia, schizophrenia, colon cancer, and neuroblastoma.

Long Name

Coiled-coil DIX1/DIX Domain Containing 1

Alternate Names

Dixdc1, Dixin, Kiaa1735

Entrez Gene IDs

85458 (Human); 330938 (Mouse); 363062 (Rat)

Gene Symbol

DIXDC1

UniProt

NP_001033043.1 (Human)

Additional Ccd1/DIXDC1 Products

Product Documents for Ccd1/DIXDC1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Ccd1/DIXDC1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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