CCR2 Antibody (2D8) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-35333

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Primate (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2b Lambda Clone # 2D8

Format

BSA Free

Concentration

1.0 mg/ml

View all CCR2 Antibodies »

Product Summary for CCR2 Antibody (2D8) - BSA Free

Immunogen

A synthetic peptide made to an N-terminal portion of the human CCR2 protein (between residues 1-100)

Localization

Cell membrane

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Lambda

Scientific Data Images for CCR2 Antibody (2D8) - BSA Free

Western Blot: CCR2 Antibody (2D8)BSA Free [NBP2-35333]

Western Blot: CCR2 Antibody (2D8)BSA Free [NBP2-35333]

Western Blot: CCR2 Antibody (2D8) [NBP2-35333] - Analysis of CCR2 [2D8] in Molt4 lysate
Immunohistochemistry-Paraffin: CCR2 Antibody (2D8) - BSA Free [NBP2-35333]

Immunohistochemistry-Paraffin: CCR2 Antibody (2D8) - BSA Free [NBP2-35333]

Immunohistochemistry-Paraffin: CCR2 Antibody (2D8) [NBP2-35333] - Analysis of FFPE tissue section of human esophageal squamous cell carcinoma (SCC) using CCR2 antibody (clone 2D8) at 5 ug/ml concentration. The cancer cells depicted strong cytoplasmic-membranous immunostaining, whereas the cells of tumor stroma were largely negative for CCR2 immunopositivity.
Immunohistochemistry-Paraffin: CCR2 Antibody (2D8) - BSA Free [NBP2-35333]

Immunohistochemistry-Paraffin: CCR2 Antibody (2D8) - BSA Free [NBP2-35333]

Immunohistochemistry-Paraffin: CCR2 Antibody (2D8) [NBP2-35333] - Analysis of FFPE tissue section of human breast using CCR2 antibody (clone 2D8) at 5 ug/ml concentration. The glandular cells in the lobules showed a specific cytoplasmic-membranous immunostaining, whereas, the inter-lobular connective tissue did not develop any staining for CCR2.

Applications for CCR2 Antibody (2D8) - BSA Free

Application
Recommended Usage

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

2 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CCR2

CCR2, or C C chemokine receptor type 2, is a receptor for several monocyte chemo attractant proteins (MCP1, MCP3, MCP4) which specifically mediate monocyte chemotaxis. CCR2 transduces such signals by increasing the intracellular level of calcium ions. For example, MCP1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. CCR2 is also an alternative coreceptor with CD4 for HIV1 infection. CCR2 has two isoforms and has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen and thymus.

Alternate Names

CC-CKR-2, CCR2, CCR2B, CD192, CKR2, CKR2A, CMKBR2, FLJ78302, MCP-1-R

Entrez Gene IDs

729230 (Human)

Gene Symbol

CCR2

UniProt

P41597 (Human)

Additional CCR2 Products

Product Documents for CCR2 Antibody (2D8) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CCR2 Antibody (2D8) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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