CCR8 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-709

Novus Biologicals, part of Bio-Techne
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NB100-709
NB100-709-0.025mg
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Key Product Details

Species Reactivity

Mouse

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

1.0 mg/ml

View all CCR8 Antibodies »

Product Specifications

Immunogen

Synthetic peptide: PNVTMTDYYPDFFTAPCDAEFLLRGSM, corresponding to amino acids 7-33 of Mouse CCR8.

Localization

Cell Membrane

Specificity

This recognizes CCR8 (50 kDa). The peptide sequence is < 50 % identical to other mouse chemokine receptors in this region.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for CCR8 Antibody

Immunohistochemistry-Paraffin: CCR8 Antibody [NB100-709]

Immunohistochemistry-Paraffin: CCR8 Antibody [NB100-709]

Immunohistochemistry-Paraffin: CCR8 Antibody [NB100-709] - Section of mouse spleen.

Applications for CCR8 Antibody

Application
Recommended Usage

ELISA

1:50000

Immunohistochemistry

1:200

Immunohistochemistry-Paraffin

1:200

Western Blot

1:500
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

10mM KHPO4 and 0.14M NaCl, BSA

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: CCR8

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation regulated cytokine (TARC) and macrophage inflammatory protein 1 beta (MIP1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. CCR8 expression has been reported in spleen and thymus, natural killer cells, monocytes, and T cells, and at lower levels in peripheral blood leukocytes. CCR* is also believed to be alternative coreceptor with CD4 for HIV-1 infection.

Alternate Names

CCR8, CD198, CDw198, ChemR1, CKRL1, GPRCL1, TER-1

Entrez Gene IDs

12776 (Mouse)

Gene Symbol

CCR8

UniProt

P56484

Additional CCR8 Products

Product Documents for CCR8 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for CCR8 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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