CD21 Antibody (Bu33) [Janelia Fluor® 669]

Novus Biologicals, part of Bio-Techne | Catalog # NB100-63574JF669

Clone Bu33 was used by HLDA to establish CD designation.
Novus Biologicals, part of Bio-Techne
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NB100-63574JF669
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Immunohistochemistry-Paraffin

Label

Janelia Fluor 669

Antibody Source

Monoclonal Mouse IgG1 Clone # Bu33

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all CD21 Antibodies »

Product Specifications

Immunogen

Made to Human CD21

Reactivity Notes

Predicted cross-reactivities: Equine

Specificity

NB100-63574 recognizes human CD21, a 145kD cell surface glycoprotein expressed by mature B lymphocytes, follicular dendritic cells, subsets of normal thymocytes and subsets of T cells. The CD21 molecule acts as a receptor for CD23, for complement components C3d, C3dg and iC3b and for Epstein Barr Virus. CD21 is part of the signalling complex that is linked to CD19, CD81 and phosphatidylinositol-3-kinase.

Marker

Histiocytic Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for CD21 Antibody (Bu33) [Janelia Fluor® 669]

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: CD21

CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.

Alternate Names

C3DR, CD21, CR2

Gene Symbol

CR2

Additional CD21 Products

Product Documents for CD21 Antibody (Bu33) [Janelia Fluor® 669]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for CD21 Antibody (Bu33) [Janelia Fluor® 669]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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