CD23/Fc epsilon RII Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-85776

Novus Biologicals, part of Bio-Techne
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NBP1-85776
NBP1-85776-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CD23/Fc epsilon RII Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: VHARYACDDMEGQLVSIHSPEEQDFLTKHASHTGSWIGLRNLDLKGEFIWVDGSHVDYSNWAPGEPTSRSQGEDCVMMRGSGRWNDAFCDRKLGAWVCDRLATCTPPASEGSAESMGPDSRPDP

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CD23/Fc epsilon RII Antibody

Immunohistochemistry-Paraffin: CD23/Fc epsilon RII Antibody [NBP1-85776]

Immunohistochemistry-Paraffin: CD23/Fc epsilon RII Antibody [NBP1-85776]

Immunohistochemistry-Paraffin: CD23/Fc epsilon RII Antibody [NBP1-85776] - Staining in human lymph node and liver tissues using anti-FCER2 antibody. Corresponding FCER2 RNA-seq data are presented for the same tissues.
Western Blot: CD23/Fc epsilon RII Antibody [NBP1-85776]

Western Blot: CD23/Fc epsilon RII Antibody [NBP1-85776]

Western Blot: CD23/Fc epsilon RII Antibody [NBP1-85776] - Analysis in control (vector only transfected HEK293T lysate) and FCER2 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).
Immunohistochemistry-Paraffin: CD23/Fc epsilon RII Antibody [NBP1-85776]

Immunohistochemistry-Paraffin: CD23/Fc epsilon RII Antibody [NBP1-85776]

Immunohistochemistry-Paraffin: CD23/Fc epsilon RII Antibody [NBP1-85776] - Staining of human liver shows low expression as expected.
View 1 more images

Applications for CD23/Fc epsilon RII Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CD23/Fc epsilon RII

The CD23 antigen is the low affinity IgE Fc receptor, which is a 49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a

Long Name

Fc epsilon Receptor II

Alternate Names

CD23, CLEC4J, Fc epsilon RII, FCER2, Fcer2a, FceRII, IGEBF, Ly-42

Gene Symbol

FCER2

Additional CD23/Fc epsilon RII Products

Product Documents for CD23/Fc epsilon RII Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for CD23/Fc epsilon RII Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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