CD3 zeta Antibody (4D10A6) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-47337

Novus Biologicals, part of Bio-Techne
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NBP1-47337
NBP1-47337-0.025mg
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Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA, Flow Cytometry, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # 4D10A6

Format

BSA Free

Concentration

1 mg/ml

View all CD3 zeta/CD247 Antibodies »

Product Summary for CD3 zeta Antibody (4D10A6) - BSA Free

Immunogen

Purified recombinant fragment of human CD3 zeta expressed in E. Coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for CD3 zeta Antibody (4D10A6) - BSA Free

Immunocytochemistry/ Immunofluorescence: CD3 zeta Antibody (4D10A6) - BSA Free [NBP1-47337]

Immunocytochemistry/ Immunofluorescence: CD3 zeta Antibody (4D10A6) - BSA Free [NBP1-47337]

Immunocytochemistry/Immunofluorescence: CD3 zeta Antibody (4D10A6) [NBP1-47337] - Immunofluorescence analysis of peripheral blood T cells using CD3 mouse mAb (A) and flow cytometric analysis of eripheral blood T cells using CD3 mouse mAb (B).
Flow Cytometry: CD3 zeta Antibody (4D10A6) - BSA Free [NBP1-47337]

Flow Cytometry: CD3 zeta Antibody (4D10A6) - BSA Free [NBP1-47337]

Flow Cytometry: CD3 zeta Antibody (4D10A6) [NBP1-47337] - FCM analysis CD3 expressed in human peripheral blood cells. Image using the Unpurified format of this antibody.

Applications for CD3 zeta Antibody (4D10A6) - BSA Free

Application
Recommended Usage

ELISA

1:10000

Immunocytochemistry/ Immunofluorescence

1:200-1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.03% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CD3 zeta/CD247

CD3 (Cluster of Differentiation 3) is a complex of proteins that associates directly with the T cell antigen receptor (TCR). Antigen binding to the TCR leads to IL-2 secretion via activation of a tyrosine phosphorylation pathway and a phospholipase C (PLC) pathway, in turn activating protein kinase C. CD3 is composed of five invariant polypeptide chains that associate to form three dimers. The five invariant chains of CD3 are labeled gamma, delta, epsilon, zeta, and eta. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Loss of the zeta chain results in the synthesis of unstable TCRs. A decrease of CD3 zeta has been described in T cells from patients with cancer, lupus and chronic infectious diseases.

Long Name

T-cell Receptor zeta

Alternate Names

CD247, CD3H, CD3Q, CD3Z, IMD25, T3Z, TCR Zeta Chain

Entrez Gene IDs

919 (Human)

Gene Symbol

CD247

Additional CD3 zeta/CD247 Products

Product Documents for CD3 zeta Antibody (4D10A6) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CD3 zeta Antibody (4D10A6) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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