CD30/TNFRSF8 Antibody (Ki-4) - Chimeric - Azide and BSA Free

This antibody is Cytof ready. This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. The antibody binds specifically to CD30/TNFRSF8, a cell membrane protein which belongs to the tumour necrosis factor receptor family. Incubation of CD30/TNFRSF8 positive L540 cells with Ki-4 antibody completely inhibits release of soluble CD30/TNFRSF8 (in contrast to Ki-3, NBP2-52682). CD30/TNFRSF8 is expressed on activated lymphocytes, and binding by its ligands TRAF2 and TRAF5 results in the activation of NF-kappaB, thereby regulating gene expression. CD30/TNFRSF8 is also associated with Hodgkin Lymphoma, and its expression acts as a tumour marker. Targeting the CD30/TNFRSF8 antigen with specific monoclonal antibodies is a possible therapy for Hodgkin's lymphoma.